Toghill P J, Smith P G, Benton P, Brown R C, Matthews H L
Br Med J. 1974 Aug 31;3(5930):545-8. doi: 10.1136/bmj.3.5930.545.
Twenty patients are described in whom liver damage appeared to be directly related to the administration of methyldopa. Sixteen had hepatitic syndromes from which they recovered on stopping methyldopa; four of these patients had recurrences of jaundice after a second course of the drug. Features suggestive of active chronic hepatitis were found in two patients. There were two deaths attributed to methyldopa, one of these being in a patient with pre-existing undiagnosed macronodular cirrhosis.
本文描述了20例肝脏损害似乎与甲基多巴的使用直接相关的患者。其中16例患有肝炎综合征，停用甲基多巴后康复；这些患者中有4例在再次使用该药物后黄疸复发。2例患者出现提示活动性慢性肝炎的特征。有2例死亡归因于甲基多巴，其中1例是患有先前未诊断出的大结节性肝硬化的患者。
