甲基多巴停药后的药物代谢与肝功能
Drug metabolism and liver function after methyldopa withdrawal.
作者信息
Ylikallio A, Sotaniemi E A
出版信息
Br J Clin Pharmacol. 1980 Aug;10(2):115-9. doi: 10.1111/j.1365-2125.1980.tb01727.x.
Abstract
1 The effects of methyldopa withdrawal on liver function and drug metabolism were investigated in ten elderly females suffering from the drug-induced orthostatic reaction and resistant hypertension. 2 There was a significant increase in serum albumin level, antipyrine metabolism and urinary excretion of D-glucaric acid 6 months after the methyldopa withdrawal. 3 The results suggest that patients treated with methyldopa might show a reduced metabolizing ability in spite of normal liver function tests.
摘要
- 对10名患有药物性直立性反应和顽固性高血压的老年女性，研究了甲基多巴撤药对肝功能和药物代谢的影响。2. 甲基多巴撤药6个月后，血清白蛋白水平、安替比林代谢及D - 葡糖醛酸的尿排泄显著增加。3. 结果提示，尽管肝功能检查正常，但接受甲基多巴治疗的患者可能表现出代谢能力降低。
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Classification of smooth muscle autoantibodies detected by immunofluorescence.通过免疫荧光检测的平滑肌自身抗体的分类
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Hepatic injury and drug metabolism in patients with alpha-methyldopa-induced liver damage.α-甲基多巴所致肝损伤患者的肝损伤与药物代谢
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