Wilson L M, Draper G J
Br Med J. 1974 Aug 3;3(5926):301-7. doi: 10.1136/bmj.3.5926.301.
The natural history of neuroblastoma and factors affecting survival for this disease were studied in an unselected group of children notified to cancer registries in Britain during 1962-7. The three-year survival rate based on 487 cases was 23%; many of the cases were followed up for more than five years, and this made it possible to calculate long-term survival and recurrence rates. There were only five deaths among 110 cases followed for more than three years, 64 of the survivors having been followed for more than five years. Factors affecting the prognosis included age at diagnosis, site, histological grade at diagnosis, and the sex of the child. The interrelationship between these factors together with their effect on prognosis were analysed, and in particular we attempted to elucidate factors which might explain our observation that girls have a significantly better survival rate than boys. Direct histological evidence and also the analyses of survival and recurrence rates seem to support the suggestion that the likelihood of maturation for this tumour is greater for girls than for boys.
1962年至197年期间，对英国癌症登记处通报的一组未经挑选的儿童神经母细胞瘤自然病史及影响该疾病生存的因素进行了研究。基于487例病例的三年生存率为23%；许多病例随访超过五年，这使得计算长期生存率和复发率成为可能。在随访超过三年的110例病例中，仅有5例死亡，64例幸存者随访超过五年。影响预后的因素包括诊断时的年龄、部位、诊断时的组织学分级以及患儿的性别。分析了这些因素之间的相互关系及其对预后的影响，特别是我们试图阐明一些因素，这些因素或许可以解释我们观察到的女孩生存率显著高于男孩这一现象。直接的组织学证据以及生存率和复发率分析似乎支持了这样一种观点，即该肿瘤女孩比男孩更易成熟。
