关于基因控制区的结构
On the structure of gene control regions.
作者信息
Wallace B, Kass T L
出版信息
Genetics. 1974 Jul;77(3):541-58. doi: 10.1093/genetics/77.3.541.
Abstract
A model emphasizing the possible genetic role of tandem duplications of reverse repeats has been developed as an extension of Crick's (1971) general model for the chromosomes of higher organisms. Although developed initially (1) to explain why random differences in the control regions of individual gene loci might confer a selective advantage on heterozygous individuals as well as (2) to offer the species a means by which such differences might be effected without mutational harm, it seems that control regions built on a foundation of tandemly duplicated reverse repeats would exhibit many properties previously observed in studies on mutable loci in various organisms.
摘要
作为对克里克（1971年）高等生物染色体通用模型的扩展，已经开发出一种强调反向重复串联复制可能的遗传作用的模型。尽管该模型最初开发的目的是（1）解释为什么单个基因座控制区域的随机差异可能会赋予杂合个体选择优势，以及（2）为物种提供一种在不造成突变危害的情况下实现这种差异的方法，但基于反向重复串联复制构建的控制区域似乎会表现出许多先前在各种生物体的可变基因座研究中观察到的特性。
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