来自海拉细胞的不均一核RNA中的双链区域。
Double-stranded regions in heterogeneous nuclear RNA from Hela cells.
作者信息
Jelinek W, Darnell J E
出版信息
Proc Natl Acad Sci U S A. 1972 Sep;69(9):2537-41. doi: 10.1073/pnas.69.9.2537.
Abstract
Heterogeneous nuclear RNA from HeLa cells contains double-stranded regions that arise by base pairing of complementary sequences that exist as parts of the same molecule (intramolecular base pairing). When denatured, the RNA sequences that form the double-stranded regions hybridize rapidly to HeLa cell DNA, suggesting that they are transcribed from reiterated sites in the genome. The messenger RNA does not contain the same class or amount of double-stranded RNA regions found in heterogeneous nuclear RNA.
摘要
来自海拉细胞的不均一核RNA含有双链区域，这些双链区域是由作为同一分子一部分存在的互补序列通过碱基配对形成的（分子内碱基配对）。变性后，形成双链区域的RNA序列会迅速与海拉细胞DNA杂交，这表明它们是从基因组中的重复位点转录而来的。信使RNA并不包含在不均一核RNA中发现的相同种类或数量的双链RNA区域。
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