Vistica D T, Rabon A, Rabinovitz M
Res Commun Chem Pathol Pharmacol. 1979 Jan;23(1):171-83.
The effect of the naturally occuring amino acids upon melphalan (L-phenylalanine mustard, L-PAM) toxicity to a host sensitive tissue, the granulocyte and macrophage precursor cells of murine bone marrow (CFU-C), was investigated. At physiological concentrations the L isomers of leucine and glutamine were found to be the most effective of the naturally occurring amino acids in reducing drug toxicity. Tyrosine, phenylalanine and methionine also protected murine CFU-C from melphalan toxicity although the amount of protection provided by these amino acids at physiological concentrations was less than that provided by leucine and glutamine. Little difference was observed in the pattern of amino acid protection of murine CFU-C and murine L1210 leukemia cells. Murine CFU-C however were more sensitive to melphalan both in the absence and presence of amino acids.
研究了天然存在的氨基酸对美法仑（L-苯丙氨酸氮芥，L-PAM）对宿主敏感组织——小鼠骨髓粒细胞和巨噬细胞前体细胞（CFU-C）毒性的影响。在生理浓度下，发现亮氨酸和谷氨酰胺的L异构体是天然存在的氨基酸中降低药物毒性最有效的。酪氨酸、苯丙氨酸和蛋氨酸也能保护小鼠CFU-C免受美法仑毒性影响，尽管这些氨基酸在生理浓度下提供的保护量少于亮氨酸和谷氨酰胺。在小鼠CFU-C和小鼠L1210白血病细胞的氨基酸保护模式上观察到的差异很小。然而，无论有无氨基酸存在，小鼠CFU-C对美法仑都更敏感。
