Milhaud G, Calmettes C
Ann Med Interne (Paris). 1979 Dec;130(12):601-5.
Radioimmunological assays of peptidic hormone levels is now an essential procedure for the diagnosis of polyadenomatosis. The diversity of pathological associations found in polyadenomatosis cannot be completely explained by the unitary theories that have been proposed. Neither the APUD system, nor the common embryonic origin, nor the reduction in calcitonin excretion can fully explain the clinical picture: a logical explanation has still to be discovered. In practice, ectopic secretions are frequent in type 2 polyadenomatosis (medullary cancer, pheochromocytoma, neurofibroma, Marfan's syndrome, hyperparathyroidism) contrary to what is observed in type 1 cases (pituitary, parathyroid, pancreas).
肽类激素水平的放射免疫测定现在是诊断多腺瘤病的一项基本程序。在多腺瘤病中发现的病理关联的多样性无法用已提出的单一理论完全解释。无论是APUD系统、共同的胚胎起源，还是降钙素排泄的减少，都不能完全解释临床症状：仍有待发现一个合理的解释。实际上，与1型病例（垂体、甲状旁腺、胰腺）中观察到的情况相反，2型多腺瘤病（髓样癌、嗜铬细胞瘤、神经纤维瘤、马凡综合征、甲状旁腺功能亢进）中异位分泌很常见。
