Brown P C, Cowell R D, Glynn L E, Jones J H
Immunology. 1974 Sep;27(3):479-85.
Immunological reactions, both immediate and delayed, were induced in guinea-pigs immunized with two sequential polyheptapeptides, poly-(Leu—Glu—Lys—Ala—Glu—Ser—Gly) and poly-(Leu—Glu—Lys—Ala—Glu—Ala—Gly). The serine-containing polymer was moderately efficient at inducing both types of immune response (7/16 immediate and 12/16 delayed), whereas the polymer containing alanine in place of serine was almost incapable of inducing a humoral response, but invariably induced cell-mediated immunity (1/15 immediate and 15/15 delayed) on primary immunization. The difference is attributed to the lower polarity of the alanine-containing polymer since other evidence exists indicating preferential stimulation of cell-mediated immunity with decreasing polarity of the antigen.
用两种连续的多聚七肽，即聚（亮氨酸 - 谷氨酸 - 赖氨酸 - 丙氨酸 - 谷氨酸 - 丝氨酸 - 甘氨酸）和聚（亮氨酸 - 谷氨酸 - 赖氨酸 - 丙氨酸 - 谷氨酸 - 丙氨酸 - 甘氨酸）对豚鼠进行免疫，诱导出了即刻和延迟的免疫反应。含丝氨酸的聚合物在诱导两种免疫反应方面具有中等效率（7/16为即刻反应，12/16为延迟反应），而用丙氨酸取代丝氨酸的聚合物几乎不能诱导体液反应，但在初次免疫时总是能诱导细胞介导的免疫（1/15为即刻反应，15/15为延迟反应）。这种差异归因于含丙氨酸聚合物较低的极性，因为有其他证据表明，随着抗原极性的降低，细胞介导的免疫受到优先刺激。
