Janeway C A
Immunology. 1969 Nov;17(5):715-21.
Several attempts were made to elicit an anamnestic antibody response in mice to 247, poly(D-Tyr, D-Glu, D-Ala), a synthetic polypeptide composed exclusively of D-amino acids. Although anamnestic responses have been repeatedly found with L-amino acid polypeptide antigens under a variety of conditions, they have not been found under similar conditions with D-amino acid polypeptides. Nevertheless, definite anamnestic responses to D-amino acid polypeptides can be evoked. A necessary condition is a long interval between primary and secondary immunization. Sufficient conditions for such a response were not established. The findings could be explained if antigen sensitive `memory' cells are generated by a primary immunization with D-amino acid polypeptides, but appear only late in the response. The possible reasons for this delay are discussed. The results are comparable to those found by others with pneumococcal polysaccharide antigens in mice.
人们进行了多次尝试，以在小鼠中引发对247（聚（D-酪氨酸、D-谷氨酸、D-丙氨酸））的回忆性抗体反应，这是一种仅由D-氨基酸组成的合成多肽。尽管在各种条件下，L-氨基酸多肽抗原反复出现回忆性反应，但在类似条件下，D-氨基酸多肽却未出现这种反应。然而，确实可以引发对D-氨基酸多肽的明确回忆性反应。一个必要条件是初次免疫和二次免疫之间要有较长的间隔。这种反应的充分条件尚未确定。如果用D-氨基酸多肽进行初次免疫会产生对抗原敏感的“记忆”细胞，但这些细胞仅在反应后期才出现，那么这些发现就可以得到解释。文中讨论了这种延迟的可能原因。这些结果与其他人在小鼠中使用肺炎球菌多糖抗原所发现的结果相当。
