溃疡病、代谢性碱中毒与甲状旁腺功能亢进：一种相互关系的机制？
Ulcer disease, metabolic alkalosis and hyperparathyroidism: A mechanism of interrelationship?
作者信息
Kaplan E L, Peskin G W, Deveney C, Way L, Jaffe B
出版信息
Ann Surg. 1974 Oct;180(4):549-57. doi: 10.1097/00000658-197410000-00019.
Abstract
In both normal volunteers and in patients with primary hyperparathyroidism, the induction of a metabolic alkalosis by infusion of sodium bicarbonate results in a decrease in serum calcium ion and in an increase of circulating parathyroid hormone concentrations. Bicarbonate infusion may serve in man as a new provocative test for release of parathyroid hormone. Furthermore, we speculate that the metabolic alkalosis which is found at times in patients with the Zollinger-Ellison syndrome and severe peptic ulcer disease may result in parathyroid gland stimulation.
摘要
在正常志愿者和原发性甲状旁腺功能亢进患者中，输注碳酸氢钠诱导代谢性碱中毒会导致血清钙离子减少和循环甲状旁腺激素浓度增加。碳酸氢钠输注可能成为人体甲状旁腺激素释放的一种新的激发试验。此外，我们推测，在佐林格-埃利森综合征和严重消化性溃疡病患者中有时发现的代谢性碱中毒可能会刺激甲状旁腺。
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本文引用的文献
1
Gastrointestinal manifestations of primary hyperparathyroidism: experience at the Mount Sinai Hospital and review of the literature.原发性甲状旁腺功能亢进的胃肠道表现：西奈山医院的经验及文献综述
J Mt Sinai Hosp N Y. 1958 Jul-Aug;25(4):339-45.
2
Role of calcium in gastric hypersecretion, parathyroid adenoma and peptic ulcer.
N Engl J Med. 1967 May 18;276(20):1122-4. doi: 10.1056/NEJM196705182762005.
3
Thyrocalcitonin and its role in calcium homeostasis.甲状腺降钙素及其在钙稳态中的作用。
J Endocrinol. 1967 Feb;37(2):155-67. doi: 10.1677/joe.0.0370155.
4
Glucagon-induced hypocalcemia.
Metabolism. 1967 Jan;16(1):35-9. doi: 10.1016/0026-0495(67)90156-4.
5
Effects of calcium on serum gastrin levels in the zollinger-Ellison syndrome.钙对佐林格-埃利森综合征患者血清胃泌素水平的影响。
N Engl J Med. 1969 Oct 16;281(16):862-6. doi: 10.1056/NEJM196910162811602.
6
Diurnal variations in the acid-base balance of blood.血液酸碱平衡的昼夜变化。
Scand J Clin Lab Invest. 1968;22(2):151-6. doi: 10.3109/00365516809160961.
7
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Ann Surg. 1968 Oct;168(4):714-9. doi: 10.1097/00000658-196810000-00015.
8
A radioimmunoassay for parathyroid hormone in man.一种用于人体甲状旁腺激素的放射免疫测定法。
Proc Soc Exp Biol Med. 1968 Jun;128(2):501-4. doi: 10.3181/00379727-128-33050.
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10
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Surgery. 1971 Aug;70(2):198-204.
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