高钙血症疾病的病理生理学与临床方面
The pathophysiology and clinical aspects of hypercalcemic disorders.
作者信息
Lee D B, Zawada E T, Kleeman C R
出版信息
West J Med. 1978 Oct;129(4):278-320.
FOR THE PURPOSES OF THIS REVIEW, THE VAST AND INCREASINGLY COMPLEX SUBJECT OF HYPERCALCEMIC DISORDERS CAN BE BROKEN DOWN INTO THE FOLLOWING CATEGORIES: (1) Physiochemical state of calcium in circulation. (2) Pathophysiological basis of hypercalcemia. (3) Causes of hypercalcemia encountered in clinical practice: causes indicated by experience at the University of California, Los Angeles; neoplasia; hyperparathyroidism; nonparathyroid endocrinopathies; pharmacological agents; possible increased sensitivity to vitamin D; miscellaneous causes. (4) Clinical manifestations and diagnostic considerations of hypercalcemic disorders. (5) The management of hypercalcemic disorders: general measures; measures for lowering serum calcium concentration; measures for correcting primary causes-the management of asymptomatic hyperparathyroidism.
为了本次综述的目的，高钙血症这一庞大且日益复杂的主题可细分为以下几类：(1) 循环中钙的理化状态。(2) 高钙血症的病理生理基础。(3) 临床实践中遇到的高钙血症病因：加利福尼亚大学洛杉矶分校经验提示的病因；肿瘤；甲状旁腺功能亢进；非甲状旁腺内分泌病；药物制剂；对维生素D可能增加的敏感性；其他病因。(4) 高钙血症的临床表现及诊断考量。(5) 高钙血症的治疗：一般措施；降低血清钙浓度的措施；纠正原发性病因的措施——无症状甲状旁腺功能亢进的治疗。
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