West R J, Fosbrooke A S, Lloyd J K
Arch Dis Child. 1974 Aug;49(8):627-32. doi: 10.1136/adc.49.8.627.
Studies of carbohydrate metabolism in 6 children with partial lipodystrophy (none of whom had evidence of renal disease) showed raised fasting serum insulin concentrations. In 4 of the children hyperinsulinaemia was found after oral glucose. Plasma glucose levels within the normal range in all tests indicated that the hyperinsulinaemia was due to insulin resistance. Plasma growth hormone concentration was normal in all children, and plasma cortisol concentration was normal in 5. Concentrations of plasma nonesterified fatty acid (NEFA), serum triglyceride, and cholesterol in fasting blood were normal. Adipose tissue from nondystrophic areas showed an increased proportion of palmitoleic acid. No abnormality of the autonomic nervous system was found. Treatment of 2 patients with propranolol did not improve their lipodystrophy. The metabolic abnormalities present at an early age of the disease show that partial lipodystrophy should not be regarded only as a cosmetic disorder.
对6名部分脂肪营养不良患儿（均无肾病证据）的碳水化合物代谢研究显示，空腹血清胰岛素浓度升高。4名儿童口服葡萄糖后出现高胰岛素血症。所有测试中血浆葡萄糖水平均在正常范围内，表明高胰岛素血症是由胰岛素抵抗引起的。所有儿童的血浆生长激素浓度正常，5名儿童的血浆皮质醇浓度正常。空腹血中血浆非酯化脂肪酸（NEFA）、血清甘油三酯和胆固醇浓度正常。非营养不良区域的脂肪组织中棕榈油酸比例增加。未发现自主神经系统异常。2例患者用普萘洛尔治疗并未改善其脂肪营养不良。该病早期出现的代谢异常表明，部分脂肪营养不良不应仅被视为一种美容疾病。
