Irvin T T, Hunt T K
Ann Surg. 1974 Nov;180(5):765-72. doi: 10.1097/00000658-197411000-00010.
It has been suggested that colonic healing is impaired in malnourished subjects, but there have been no biochemical studies of the effect of malnutrition on colonic healing. The effects of malnutrition on the colon and the healing of colonic anastomoses were studied in rats fed a protein-free diet. Test animals were compared with control animals of similar age, and control animals of similar weight. There was a significant reduction in the body weight, total serum proteins and serum albumin of animals starved of protein. Malnutrition resulted in a reduction in the weight of the uninjured colon, and an increase in the colonic collagen concentration. There was a significant reduction in the collagen content of the colon in animals starved of protein for seven weeks, and the collagen content of anastomoses in these animals was significantly lower than the value in control animals. Anastomotic edema occurred during colon healing in animals starved for seven weeks. Measurements of colonic bursting pressure were an inaccurate guide to colonic healing. It is concluded that severe malnutrition resulting in 34% loss of body weight had an adverse effect on colonic healing.
有人提出，营养不良的受试者结肠愈合受损，但尚未有关于营养不良对结肠愈合影响的生化研究。在喂食无蛋白饮食的大鼠中研究了营养不良对结肠及结肠吻合口愈合的影响。将试验动物与年龄相似的对照动物以及体重相似的对照动物进行比较。缺乏蛋白质的动物体重、总血清蛋白和血清白蛋白显著降低。营养不良导致未受伤结肠重量减轻，结肠胶原蛋白浓度增加。缺乏蛋白质7周的动物结肠胶原蛋白含量显著降低，这些动物吻合口的胶原蛋白含量明显低于对照动物的值。饥饿7周的动物在结肠愈合过程中出现吻合口水肿。结肠破裂压力的测量对结肠愈合的指导不准确。得出的结论是，导致体重减轻34%的严重营养不良对结肠愈合有不利影响。
