Moretti A, Arcari G, Pegrassi L
Arzneimittelforschung. 1979;29(8a):1223-7.
10-Methoxy-1,6-dimethyl-ergoline-8 beta-methanol-(5-bromonicotinate) (nicergoline, Sermion) shows a strong alpha-blocking activity both in vitro and in vivo. Various studies (dog, cat, rabbit, rat, mouse, guinea-pig) show that nicergoline affects only slightly blood pressure and heart rate and increases the blood flow in brain and hind limb without affecting the splanchnic and aortic flow in normal animals. Nicergoline does not interfere with CNS functions unless applied in high doses. It stimulates the muscle oxidative metabolism and function and lacks any emetic and hallucinogenic activity. Its acute and chronic toxicity in different animal species is very low.
10-甲氧基-1,6-二甲基-麦角灵-8β-甲醇-(5-溴烟酸酯)(尼麦角林，喜得镇)在体外和体内均表现出很强的α阻断活性。多项研究(涉及狗、猫、兔、大鼠、小鼠、豚鼠)表明，尼麦角林对血压和心率影响轻微，可增加大脑和后肢的血流量，而不影响正常动物的内脏和主动脉血流量。除非大剂量应用，尼麦角林不会干扰中枢神经系统功能。它能刺激肌肉的氧化代谢和功能，且无任何催吐和致幻活性。其在不同动物物种中的急性和慢性毒性都很低。
