Moretti A
Arzneimittelforschung. 1979;29(8a):1213-23.
The effects of 10-methoxy-1,6-dimethyl-ergoline-8 beta-methanol(5-bromonicotinate) (nicergoline, Sermion) on the energy metabolism in the animal CNS during and after cerebral hypoxia and ischemia have been studied by various authors by different methodological approaches. For this purpose both electrophysiological (EEG and cortically evoked potentials) and neurochemical parameters (adenylates, creatinphosphate and some intermediates of glycolysis and Krebs cycle) were analysed in dogs and cats. These studies concordantly show that nicergoline exerts a favourable activity during the post-hypoxic and post-ischemic period. In fact the recovery of the electrophysiological and neurochemical parameters is always more rapid in nicergoline-treated animals than in controls. The effects of nicergoline on the EEG pattern, on the energy potential and citrate concentration are particularly interesting.
多位作者采用不同的方法研究了10-甲氧基-1,6-二甲基麦角灵-8β-甲醇（5-溴烟酸酯）（尼麦角林，喜得镇）对动物中枢神经系统在脑缺氧和缺血期间及之后能量代谢的影响。为此，在狗和猫身上分析了电生理参数（脑电图和皮层诱发电位）和神经化学参数（腺苷酸、磷酸肌酸以及糖酵解和三羧酸循环的一些中间产物）。这些研究一致表明，尼麦角林在缺氧和缺血后时期发挥有益作用。事实上，接受尼麦角林治疗的动物的电生理和神经化学参数的恢复总是比对照组更快。尼麦角林对脑电图模式、能量电位和柠檬酸盐浓度的影响尤其令人关注。
