Traviesa D C
J Neurol Neurosurg Psychiatry. 1974 Aug;37(8):959-62. doi: 10.1136/jnnp.37.8.959.
The determination of blood transketolase before and serially after thiamine administration, and the response of clinical symptomatology after thiamine are reported in two normomagnesaemic patients and one hypomagnesaemic patient with acute Wernicke-Korsakoff encephalopathy. The response of the depressed blood transketolase and the clinical symptoms was retarded in the hypomagnesaemic patient. Correction of hypomagnesaemia was accompanied by the recovery of blood transketolase activity and total clearing of the ophthalmoplegia in this patient, suggesting that hypomagnesaemia may be a cause of the occasional thiamine refractoriness of these patients.
报告了2例血镁正常和1例血镁过低的急性韦尼克-科尔萨科夫脑病患者在给予硫胺素之前及之后连续测定的转酮醇酶水平，以及硫胺素治疗后临床症状的反应。血镁过低的患者中转酮醇酶水平降低及临床症状的反应延迟。该患者血镁过低得到纠正后，转酮醇酶活性恢复，眼肌麻痹完全消除，这表明血镁过低可能是这些患者偶尔出现硫胺素难治性的原因。
