Mishina T, Fujiwara T, Miyakoda K, Araki H, Kobayashi T, Saitoh M, Watanabe H
Tohoku J Exp Med. 1979 Apr;127(4):339-43. doi: 10.1620/tjem.127.339.
Topical instillation of Adriamycin, 40 mg in 20 ml sterilized distilled water, was performed in 20 cases of bladder tumors every day for two weeks. In 8 cases (40%) the tumors disappeared completely, while in 5 cases (25%) tumors were reduced in size, but in 7 cases (35%) there was no effect. Therefore, the rate of effectiveness was 65%. The local bladder reaction and urethral pain were noted in all cases, as a result of which the therapy was interrupted in 2 cases. Abnormal values of red blood cells, white blood cells and platelets were not observed. In 3 cases the serum level of Adriamycin was only trace 1 or 2 hr after instillation. In conclusion, Mitomycin C was thought to be superior to Adriamycin as far as the effectiveness and irritability on the normal bladder epithelium were concerned.
对20例膀胱肿瘤患者，每天在20毫升灭菌蒸馏水中加入40毫克阿霉素进行膀胱局部灌注，持续两周。8例（40%）肿瘤完全消失，5例（25%）肿瘤体积缩小，但7例（35%）无效。因此，有效率为65%。所有病例均出现膀胱局部反应和尿道疼痛，2例因此中断治疗。未观察到红细胞、白细胞和血小板值异常。3例在灌注后1或2小时血清阿霉素水平仅为微量。总之，就对正常膀胱上皮的有效性和刺激性而言，丝裂霉素C被认为优于阿霉素。
