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Synthetic analgesics. Synthesis and pharmacology of the diastereoisomers of N-(3-methyl-1-(2-phenylethyl)-4-piperidyl)-N-phenylpropanamide and N-(3-methyl-1-(1-methyl-2-phenylethyl)-4-piperidyl)-N-phenylpropanamide.

作者信息

Van Bever W F, Niemegeers C J, Janssen P A

出版信息

J Med Chem. 1974 Oct;17(10):1047-51. doi: 10.1021/jm00256a003.

DOI:10.1021/jm00256a003
PMID:4420811
Abstract
摘要

相似文献

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Synthetic analgesics. Synthesis and pharmacology of the diastereoisomers of N-(3-methyl-1-(2-phenylethyl)-4-piperidyl)-N-phenylpropanamide and N-(3-methyl-1-(1-methyl-2-phenylethyl)-4-piperidyl)-N-phenylpropanamide.
J Med Chem. 1974 Oct;17(10):1047-51. doi: 10.1021/jm00256a003.
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[Studies on potent analgesics. V. Synthesis and analgesic activity of the ester derivatives of N-(1-(2-hydroxy-2-phenylethyl)-3-methyl-4-piperidyl)-N-phenylpropan amide (7302)].
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[Studies on potent analgesics. VII. Synthesis and analgesic activity of diastereoisomers of 1-beta-hydroxy-3-methylfentanyl (7302) and related compounds].[强效镇痛药的研究。VII. 1-β-羟基-3-甲基芬太尼（7302）及相关化合物的非对映异构体的合成与镇痛活性]
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Stereochemical studies on medicinal agents. 17. Synthesis, absolute configuration, and analgetic potency of enantiomeric diastereomers of 3-ethyl and 3-propyl derivatives of 1-methyl-4-phenyl-4-propionoxypiperidine.药物的立体化学研究。17. 1-甲基-4-苯基-4-丙酰氧基哌啶的3-乙基和3-丙基衍生物对映体非对映异构体的合成、绝对构型及镇痛效力
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Studies on synthesis and relationship between analgesic activity and receptor affinity for 3-methyl fentanyl derivatives.
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3,5-Propanopiperidine derivatives as potential analgesics.
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Enantiomers of diastereomeric cis-N-[1-(2-hydroxy-2-phenylethyl)- 3-methyl-4-piperidyl]-N-phenylpropanamides: synthesis, X-ray analysis, and biological activities.非对映体顺式-N-[1-(2-羟基-2-苯乙基)-3-甲基-4-哌啶基]-N-苯基丙酰胺的对映体：合成、X射线分析及生物活性
J Med Chem. 1995 Apr 28;38(9):1547-57. doi: 10.1021/jm00009a015.

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