Dardenne M, Papiernik M, Bach J F, Stutman O
Immunology. 1974 Aug;27(2):299-304.
Serum thymic factor (TF) has been tested by its action on spleen rosette-forming cells from adult thymectomized mice. It has been confirmed in a blind study using coded serum samples that TF disappeared early after adult thymectomy and reappeared after grafting a thymus, either as a free graft or enclosed in cell impermeable diffusion chambers. Similar reconstitution was also obtained by grafting a non-lymphoid epithelial thymoma or pure epithelial thymus, obtained by incubation of a thymus within a diffusion chamber in an intermediate host. Conversely, TF levels were not restored in thymectomized animals treated with dispersed spleen cells or with dispersed thymic lymphocytes.
血清胸腺因子（TF）已通过其对成年去胸腺小鼠脾玫瑰花结形成细胞的作用进行了检测。在一项使用编码血清样本的盲法研究中证实，TF在成年去胸腺后早期消失，在移植胸腺后重新出现，移植的胸腺可以是游离移植，也可以封装在细胞不可渗透的扩散室中。通过移植非淋巴上皮胸腺瘤或纯上皮胸腺也获得了类似的重建效果，这些组织是通过在中间宿主的扩散室中孵育胸腺获得的。相反，用分散的脾细胞或分散的胸腺淋巴细胞处理的去胸腺动物中，TF水平未恢复。
