Stimson W H, Crilly P J
Immunology. 1981 Oct;44(2):401-7.
Rat thymic epithelial cells were cultured for 39 days in the presence of various concentrations of oestradiol, testosterone, progesterone and corticosterone and the supernatants assessed for effects on the stimulation of cells from the thymus, bone marrow, lymph nodes and spleen, with several agents. All the steroids, except progesterone, were found to significantly regulate the secretion of immunoregulatory factors by the epithelial cells at physiological levels but the effects were dose dependent. Fractionation of active supernatants indicated that the capacity to enhance or depress cellular proliferation was mainly associated with substances having molecular weights greater than 30,000 or less than 1000, respectively. This study supports the idea that certain steroids can influence the immune response indirectly through the thymus.
将大鼠胸腺上皮细胞在不同浓度的雌二醇、睾酮、孕酮和皮质酮存在的情况下培养39天，然后评估上清液对几种试剂刺激胸腺、骨髓、淋巴结和脾脏细胞的影响。结果发现，除孕酮外，所有类固醇在生理水平上均能显著调节上皮细胞免疫调节因子的分泌，但其作用呈剂量依赖性。对活性上清液进行分级分离表明，增强或抑制细胞增殖的能力分别主要与分子量大于30,000或小于1000的物质有关。本研究支持了某些类固醇可通过胸腺间接影响免疫反应这一观点。
