用于肾上腺成像的碘-131标记的6β-碘甲基-19-去甲雄甾-5(10)-烯-3β-醇和19-碘雄甾-5-烯-3β-醇的合成
Synthesis of iodine-131 labeled 6 beta-iodomethyl-19-norsitost-5(10)-en-3 beta-ol and 19-iodositost-5-en-3 beta-ol for adrenal imaging.
作者信息
Komatsu H, Yamauchi S, Shimoirisa H, Ito T, Maeda M, Kojima M
出版信息
Steroids. 1979 Mar;33(3):339-45. doi: 10.1016/0039-128x(79)90010-2.
PMID:442128
Abstract
6 BETA-Iodomethyl-19-norsitost-5(10)-en-3 beta-ol (V) was synthesized by homoallylic rearrangement of 19-iodositost-5-en-3 beta-ol (IV), which was obtained by the hydrolysis of 19-iodositost-5-en-3 beta-ol acetate (III) derived from the displacement of sitost-5-ene-3 beta, 19-diol 3-acetate 19-p-toluenesulfonate (I) with sodium iodide in isopropanol. The radioiodinated IV and V were prepared by isotope exchange with sodium iodide-I-131.
摘要
6β-碘甲基-19-去甲豆甾-5(10)-烯-3β-醇（V）通过19-碘豆甾-5-烯-3β-醇（IV）的高烯丙基重排反应合成，后者是由豆甾-5-烯-3β,19-二醇3-乙酸酯19-对甲苯磺酸酯（I）在异丙醇中与碘化钠发生取代反应得到的19-碘豆甾-5-烯-3β-醇乙酸酯（III）水解制得。放射性碘化的IV和V通过与碘化钠-I-131进行同位素交换来制备。
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