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急性中风患者血清多巴胺-β-羟化酶活性

Serum dopamine-beta-hydroxylase activity in acute stroke.

作者信息

Kanda T, Gotoh F, Yamamoto M, Sakai F, Takeoka T, Takagi Y

出版信息

Stroke. 1979 Mar-Apr;10(2):168-73. doi: 10.1161/01.str.10.2.168.

DOI:10.1161/01.str.10.2.168
PMID:442140
Abstract

Serum dopamine-beta-hydroxylase (DBH) activity was measured in 34 patients with acute cerebrovascular disease. The serum level of DBH activity showed its highest value soon after the onset of stroke and then gradually decreased over the next few days. After reaching its lowest level, the DBH activity again showed a slight increase. There was no direct relationship between serum DBH activity and total serum protein, or blood pressure. In 8 of 12 patients, DBH activity in the cerebral venous blood was higher than that in the arterial blood. These results suggest that rapid release of DBH into the circulating blood occurred after stroke, presumably from sympathetic nerve endings in the vessels or organs, including the brain.

摘要

对34例急性脑血管病患者测定了血清多巴胺-β-羟化酶(DBH)活性。血清DBH活性水平在卒中发作后很快达到最高值,随后在接下来的几天逐渐下降。在达到最低水平后,DBH活性再次略有升高。血清DBH活性与血清总蛋白或血压之间无直接关系。12例患者中有8例,脑静脉血中的DBH活性高于动脉血中的活性。这些结果提示,卒中后DBH迅速释放入循环血液,推测来自包括脑在内的血管或器官中的交感神经末梢。

相似文献

1
Serum dopamine-beta-hydroxylase activity in acute stroke.急性中风患者血清多巴胺-β-羟化酶活性
Stroke. 1979 Mar-Apr;10(2):168-73. doi: 10.1161/01.str.10.2.168.
2
[Changes in plasma dopamine-beta-hydroxylase activity in acute cerebrovascular accidents (author's transl)].急性脑血管意外时血浆多巴胺-β-羟化酶活性的变化(作者译)
No To Shinkei. 1978 Nov;30(11):1201-8.
3
[Changes in plasma dopamine-beta-hydroxylase activity in patients with acute subarachnoid hemorrhage (author's transl)].急性蛛网膜下腔出血患者血浆多巴胺-β-羟化酶活性的变化(作者译)
No To Shinkei. 1979 Aug;31(8):771-7.
4
[Level of dopamine beta-hydroxylase activity in subarachnoid hemorrhage treated conservatively and surgically].[保守治疗和手术治疗的蛛网膜下腔出血中多巴胺β-羟化酶活性水平]
Neurol Neurochir Pol. 1990 May-Aug;24(3-4):172-8.
5
[Creatine kinase BB activity in the serum of patients with cerebrovascular diseases].[脑血管疾病患者血清中的肌酸激酶BB活性]
Nervenarzt. 1985 Aug;56(8):417-22.
6
Clinical significance of serum creatine phosphokinase activity in cerebrovascular diseases.血清肌酸磷酸激酶活性在脑血管疾病中的临床意义
Tohoku J Exp Med. 1971 Oct;105(2):167-75. doi: 10.1620/tjem.105.167.
7
Dissociation of changes in enzymatic and immunoreactive rat serum dopamine bets-hydroxylase during growth and development.大鼠生长发育过程中血清多巴胺β-羟化酶的酶活性与免疫反应性变化的分离
J Pharmacol Exp Ther. 1977 May;201(2):375-85.
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Dopamine-beta-hydroxylase activity after acute myocardial infarction.
Jpn Heart J. 1977 May;18(3):348-56. doi: 10.1536/ihj.18.348.
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Dopamine-beta-hydroxylase activity after acute myocardial infarction.
Recent Adv Stud Cardiac Struct Metab. 1976;12:425-9.
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Serum dopamine-beta-hydroxylase activity and blood pressure.血清多巴胺-β-羟化酶活性与血压
Mayo Clin Proc. 1977 Jun;52(6):374-8.

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Behav Pharmacol. 2018 Oct;29(7):638-653. doi: 10.1097/FBP.0000000000000432.