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Pharmacokinetics of tranexamic acid after intravenous administration to normal volunteers.

作者信息

Eriksson O, Kjellman H, Pilbrant A, Schannong M

出版信息

Eur J Clin Pharmacol. 1974 Aug 23;7(5):375-80. doi: 10.1007/BF00558210.

DOI:10.1007/BF00558210
PMID:4422030
Abstract
摘要

相似文献

1
Pharmacokinetics of tranexamic acid after intravenous administration to normal volunteers.氨甲环酸静脉注射给正常志愿者后的药代动力学。
Eur J Clin Pharmacol. 1974 Aug 23;7(5):375-80. doi: 10.1007/BF00558210.
2
Local application of an antifibrinolytic in tonsillectomy. A double-blind study.抗纤溶剂在扁桃体切除术中的局部应用。一项双盲研究。
J Laryngol Otol. 1974 Jun;88(6):565-8. doi: 10.1017/s0022215100079081.
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Effect of reptilase on respiratory insufficiency induced by intravenous infusion of thrombin and AMCA (tranexamic acid) in the dog.蛇毒凝血酶对犬静脉输注凝血酶和氨甲环酸（传明酸）所致呼吸功能不全的影响。
Bibl Anat. 1973;12:254-9.
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Pharmacokinetics of cicloxilic acid in the rat.环氯昔酸在大鼠体内的药代动力学
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Pharmacokinetics and absolute bioavailability of intramuscular tranexamic acid in man.氨甲环酸在人体中的药代动力学及绝对生物利用度。
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6
Passage of tranexamic acid (AMCA) to semen in man and its effect on the fibrinolytic activity and on migration of spermatozoa.氨甲环酸（AMCA）在男性体内向精液的传递及其对纤溶活性和精子迁移的影响。
Fertil Steril. 1973 Jul;24(7):517-20. doi: 10.1016/s0015-0282(16)39791-6.
7
[Tranexamic acid, a new antifibrinolytic agent].[氨甲环酸，一种新型抗纤溶药物]
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Pharmacokinetics and bioavailability of tranexamic acid.氨甲环酸的药代动力学和生物利用度。
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Tranexamic acid--its use in controlling dental post-operative bleeding in patients with defective clotting mechanisms.氨甲环酸——其在凝血机制有缺陷的患者控制牙科术后出血中的应用。
Br J Oral Surg. 1973 Nov;11(2):155-64. doi: 10.1016/0007-117x(73)90035-8.
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[Value of tranexamic acid in extracapsular tonsillectomy in adults].氨甲环酸在成人扁桃体囊外摘除术中的价值
JFORL J Fr Otorhinolaryngol Audiophonol Chir Maxillofac. 1973 Feb;22(2):165-8.

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Use of tranexamic acid in trauma surgical specialties: a narrative review.氨甲环酸在创伤外科专业中的应用：一项叙述性综述。
World J Emerg Surg. 2025 Oct 10;20(1):76. doi: 10.1186/s13017-025-00649-9.
2
Comparison of Tranexamic Acid Administration Methods in Rhytidectomy: A Prospective, Randomized, Double-blind Study.氨甲环酸在除皱术中给药方法的比较：一项前瞻性、随机、双盲研究。
Plast Reconstr Surg Glob Open. 2025 Mar 3;13(3):e6559. doi: 10.1097/GOX.0000000000006559. eCollection 2025 Mar.
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Population pharmacokinetic model of tranexamic acid in patients who undergo cardiac surgery with cardiopulmonary bypass.

本文引用的文献

1
Shortcomings in pharmacokinetic analysis by conceiving the body to exhibit properties of a single compartment.将人体视为具有单室性质进行药代动力学分析时存在的缺点。
J Pharm Sci. 1968 Jan;57(1):117-23. doi: 10.1002/jps.2600570123.
2
AMCA (aminomethyl cyclohexane carboxylic acid, Cyklo-kapron) a potent haemostatic agent in urinary tract bleeding.氨基甲基环己烷羧酸（AMCA，环已基丙氨酸）是一种治疗泌尿道出血的强效止血剂。
Scand J Urol Nephrol. 1969;3(3):169-76. doi: 10.3109/00365596909135400.
3
Role of urokinase and tissue activator in sustaining bleeding and the management thereof with EACA and AMCA.
接受体外循环心脏手术患者中氨甲环酸的群体药代动力学模型。
Eur J Clin Pharmacol. 2025 Mar;81(3):441-449. doi: 10.1007/s00228-025-03802-0. Epub 2025 Jan 16.
4
The efficacy of preoperative tranexamic acid administration among patients undergoing arthroscopic rotator cuff repair: A systematic review and meta-analysis of randomized controlled trials.关节镜下肩袖修补术患者术前使用氨甲环酸的疗效：一项随机对照试验的系统评价和荟萃分析
Shoulder Elbow. 2024 Oct;16(6):595-604. doi: 10.1177/17585732231207972. Epub 2023 Oct 17.
5
Association of single bolus versus bolus followed by infusion of tranexamic acid with blood loss in adolescent idiopathic scoliosis surgery.青少年特发性脊柱侧凸手术中单次推注与推注后输注氨甲环酸与失血的相关性
Perioper Med (Lond). 2024 Sep 30;13(1):94. doi: 10.1186/s13741-024-00452-1.
6
Tranexamic acid in a mouse model of cerebral amyloid angiopathy: setting the stage for a novel stroke treatment approach.氨甲环酸在脑淀粉样血管病小鼠模型中的应用：为新型中风治疗方法奠定基础。
Res Pract Thromb Haemost. 2023 Aug 9;7(6):102166. doi: 10.1016/j.rpth.2023.102166. eCollection 2023 Aug.
7
Is Combining Two Different Routes of TXA Administration an Effective Blood Conserving Strategy for Total Knee Arthroplasty.联合两种不同的氨甲环酸给药途径对全膝关节置换术而言是一种有效的血液保护策略吗？
Indian J Orthop. 2023 Apr 5;57(6):868-875. doi: 10.1007/s43465-023-00875-w. eCollection 2023 Jun.
8
Safety and Efficacy of Local Tranexamic Acid for the Prevention of Surgical Bleeding in Soft-Tissue Surgery: A Review of the Literature and Recommendations for Plastic Surgery.局部氨甲环酸预防软组织手术中手术出血的安全性和有效性：文献综述及整形外科学建议。
Plast Reconstr Surg. 2022 Mar 1;149(3):774-787. doi: 10.1097/PRS.0000000000008884.
9
INTRAARTICULAR EPSILON AMINOCAPROIC ACID VERSUS TRANEXAMIC ACID IN TOTAL KNEE ARTHROPLASTY.全膝关节置换术中关节内使用ε-氨基己酸与氨甲环酸的比较
Acta Ortop Bras. 2021 Nov-Dec;29(6):312-315. doi: 10.1590/1413-785220212906242008.
10
Automatic and renewable micro-solid-phase extraction based on bead injection lab-on-valve system for determination of tranexamic acid in urine by UHPLC coupled with tandem mass spectrometry.基于微珠进样阀上实验室系统的自动可再生微固相萃取结合超高效液相色谱-串联质谱法测定尿液中的氨甲环酸
Anal Bioanal Chem. 2022 Jan;414(1):649-659. doi: 10.1007/s00216-021-03606-y. Epub 2021 Aug 19.
尿激酶和组织激活剂在持续出血中的作用及其用6-氨基己酸和氨甲环酸的处理
Ann N Y Acad Sci. 1968 Jun 28;146(2):642-58. doi: 10.1111/j.1749-6632.1968.tb20322.x.
4
Antifibrinolytic therapy with Cyklokapron in connection with prostatectomy. A double blind study.
Scand J Urol Nephrol. 1969;3(3):177-82. doi: 10.3109/00365596909135401.
5
[Intestinal absorption, distribution and elimination of 4-aminomethylcyclohexanecarboxylic acid (AMCHA) and epsilon-aminocaproic acid (ACA) in humans].[4-氨甲基环己烷羧酸（AMCHA）和ε-氨基己酸（ACA）在人体中的肠道吸收、分布及消除]
Naunyn Schmiedebergs Arch Exp Pathol Pharmakol. 1967;256(2):160-8.