乳腺癌辅助化疗期间出现闭经的患者的激素研究。

Hormonal study in patients developing amenorrhea during adjuvant chemotherapy for breast cancer.

作者信息

Recchione C, Rossi A

出版信息

Tumori. 1979 Feb 28;65(1):93-7. doi: 10.1177/030089167906500110.

Abstract

The sera of 15 premenopausal women with operable breast cancer and who had developed amenorrhea during adjuvant chemotherapy with cyclophosphamide + methotrexate + fluorouracil were analyzed for the following hormones: 17-beta-estradiol, luteinizing hormone, thyroid stimulating hormone and prolactin. The blood levels did not differ significantly from those found in patients operated on for breast cancer and in spontaneous menopause (controls). These origins suggest that the amenorrhea induced by CMF chemotherapy is of ovarian origin.

摘要

对15名患有可手术乳腺癌且在接受环磷酰胺+甲氨蝶呤+氟尿嘧啶辅助化疗期间出现闭经的绝经前女性的血清进行了以下激素分析：17-β-雌二醇、促黄体生成素、促甲状腺激素和催乳素。其血中水平与接受乳腺癌手术的患者及自然绝经者（对照组）的水平无显著差异。这些结果表明，CMF化疗所致闭经源于卵巢。