Laufer M, Ashkenazi C, Katz D, Wolman M
Br J Exp Pathol. 1974 Jun;55(3):233-6.
Skin incisions were made in each of adult female white Yorkshire pigs. One set of 3 incisions was made on the back and one on the side of the animal. In each site one incision was longitudinal, another transverse to the length of the animal, and a third was longitudinal but at an angle of about 45° to the surface. Disposition of fibroblasts, new reticulin and collagen fibres was studied at 5, 15 and 30 days after the operations. No significant differences in fibre alignment were seen between the longitudinal and the transverse, and the back and the flank wounds. In the oblique wounds the cells and fibres ran in the direction of the incision and perpendicular to it rather than in relation to the direction of the pre-existing collagen. The data indicate that the orientation of cells and fibres might be due to chemotactic influence of the traumatized area rather than to mechanical factors or to pre-existing structural arrangement.
在每只成年雌性白色约克夏猪身上做皮肤切口。在动物背部做一组3个切口，在侧面做一个切口。在每个部位，一个切口是纵向的，另一个与动物体长方向垂直，第三个是纵向但与表面呈约45°角。在手术后5天、15天和30天研究成纤维细胞、新的网状纤维和胶原纤维的分布情况。纵向和横向切口之间以及背部和侧腹伤口之间在纤维排列上没有显著差异。在斜向伤口中，细胞和纤维沿切口方向并与其垂直排列，而不是与先前存在的胶原方向相关。数据表明，细胞和纤维的取向可能是由于创伤区域的趋化作用，而不是机械因素或先前存在的结构排列。
