Archer H G, Barnett S, Irving S, Middleton K R, Seal D V
Department of Pharmacy, Northwick Park Hospital, Harrow, UK.
J Exp Pathol (Oxford). 1990 Apr;71(2):155-70.
An established wound model in the pig has been modified using a Stomahesive ring to enable study of the effects of fluids used in wound care. Full thickness wounds (up to 9 mm deep) were treated with the substances under test. Each application was held in place with a Stomahesive flange, the inner part of which had been excised as far as the hard plastic ring. All dressings were then covered with OpSite which allowed gaseous exchange whilst retaining treatment fluids and secretions. Wounds were treated immediately and at 2 and 4 days. The experiment was terminated after 7 days and the whole wound, with dressing, was excised for histological examination. The wounds covered with OpSite alone and those treated with sugar paste under Opsite were found to be infilled with granulation tissue over which epidermal migration was taking place. Those wounds which had been packed with gauze, to which had been added one of the following: chlorhexidine gluconate 0.2%, Irgasan 0.2%, povidone iodine 0.8% or EUSOL half-strength, showed delayed healing in that less infilling had taken place over the same time period. This delay could be attributed to the nature of the chemicals used and/or the influence of gauze packing. This delay in the healing of wounds treated with chemical agents was least with EUSOL half-strength and greatest with chlorhexidine. No toxic effects were observed with sugar paste which may be preferable to antiseptics for the management of dirty or infected wounds.
一种已建立的猪伤口模型已通过使用造口粘贴环进行改良，以便能够研究伤口护理中所使用液体的效果。用受试物质处理全层伤口（深度达9毫米）。每次涂抹均用造口粘贴法兰固定，其内部已切除至硬塑料环处。然后用Opsite覆盖所有敷料，Opsite可允许气体交换，同时保留处理液和分泌物。伤口在即刻、第2天和第4天进行处理。7天后终止实验，将整个带敷料的伤口切除以进行组织学检查。发现仅用Opsite覆盖的伤口以及在Opsite下用糖膏处理的伤口充满了肉芽组织，且有表皮迁移现象。那些用纱布填充并添加了以下之一的伤口：0.2%葡萄糖酸氯己定、0.2%三氯生、0.8%聚维酮碘或半强度优琐溶液，在同一时间段内显示出愈合延迟，即填充较少。这种延迟可归因于所用化学物质的性质和/或纱布填充的影响。用化学试剂处理的伤口愈合延迟在半强度优琐溶液时最小，在葡萄糖酸氯己定时最大。未观察到糖膏有任何毒性作用，对于处理脏污或感染伤口，糖膏可能比防腐剂更可取。
