活动性慢性肝炎和原发性胆汁性肝硬化中的组织相容性抗原
Histocompatibility antigens in active chronic hepatitis and primary biliary cirrhosis.
作者信息
Galbraith R M, Eddleston A L, Smith M G, Williams R, McSween R N, Watkinson G, Dick H, Kennedy L A, Batchelor J R
出版信息
Br Med J. 1974 Sep 7;3(5931):604-5. doi: 10.1136/bmj.3.5931.604.
The frequency of antigens HL-A 1 (48%) and HL-A 8 (52%) in 54 patients with active chronic hepatitis from south-east England was significantly higher than in 89 control subjects from the same region (22% and 17% respectively). No correlation could be detected with the age and sex of the patients or with the presence of a particular immunological abnormality but the frequency of HL-A 1 and HL-A 8 was much lower in the nine patients who were positive for HBAg than in the 45 HBAg-negative cases. These results provide further evidence of the importance of genetic factors in active chronic hepatitis. In contrast the frequency of HL-A 1 and HL-A 8 in primary biliary cirrhosis, both in 45 patients from south-east England and in 28 patients from western Scotland, was not significantly different from that found in control groups from the same regions.
来自英格兰东南部的54例活动性慢性肝炎患者中，抗原HL-A 1（48%）和HL-A 8（52%）的出现频率显著高于来自同一地区的89例对照者（分别为22%和17%）。未发现与患者的年龄、性别或特定免疫异常的存在有相关性，但在9例HBAg阳性患者中HL-A 1和HL-A 8的出现频率远低于45例HBAg阴性患者。这些结果进一步证明了遗传因素在活动性慢性肝炎中的重要性。相比之下，在来自英格兰东南部的45例原发性胆汁性肝硬化患者以及来自苏格兰西部的28例患者中，HL-A 1和HL-A 8的出现频率与来自同一地区的对照组相比无显著差异。
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