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The stereochemistry of the reaction catalyzed by ethanolamine ammonia-lyase, an adenosylcobalamin-dependent enzyme. An example of racemization accompanying substitution.

作者信息

Rétey J

出版信息

J Biol Chem. 1974 Oct 10;249(19):6359-60.

PMID:4424285
Abstract
摘要

相似文献

1
The stereochemistry of the reaction catalyzed by ethanolamine ammonia-lyase, an adenosylcobalamin-dependent enzyme. An example of racemization accompanying substitution.乙醇胺氨裂解酶催化的反应的立体化学,一种依赖腺苷钴胺素的酶。伴随取代作用的外消旋化的一个例子。
J Biol Chem. 1974 Oct 10;249(19):6359-60.
2
Mechanism of action of ethanolamine ammonia-lyase, an adenosylcobalamin-dependent enzyme. Proton nuclear magnetic resonance studies of the binding of adenine nucleosides and substrate to ethanolamine ammonia-lyase.乙醇胺氨裂解酶的作用机制,一种依赖腺苷钴胺素的酶。腺嘌呤核苷和底物与乙醇胺氨裂解酶结合的质子核磁共振研究。
J Biol Chem. 1975 Oct 25;250(20):8023-9.
3
The mechanism of action of ethanolamine ammonia-lyase, an adenosylcobalamin-dependent enzyme. The source of the third methyl hydrogen in the 5'-deoxyadenosine generated from the cofactor during catalysis.乙醇胺氨裂解酶(一种依赖腺苷钴胺素的酶)的作用机制。催化过程中从辅因子生成的5'-脱氧腺苷中第三个甲基氢的来源。
J Biol Chem. 1976 Jun 25;251(12):3734-7.
4
The mechanism of action of ethanolamine ammonia-lyase, an adenosylcobalamin-dependent enzyme. Studies with isopropanolamine, a true substrate.乙醇胺氨裂解酶(一种依赖腺苷钴胺素的酶)的作用机制。以异丙醇胺(一种真正的底物)进行的研究。
J Biol Chem. 1980 Aug 10;255(15):7444-8.
5
Ethanolamine ammonia-lyase: inactivation of the holoenzyme by N2O and the mechanism of action of Coenzyme B12.乙醇胺氨裂合酶:N2O对全酶的失活作用及辅酶B12的作用机制
Bioinorg Chem. 1975 Apr;4(3):185-98. doi: 10.1016/s0006-3061(00)80102-7.
6
The mechanism of action of ethanolamine ammonia-lyase, an adenosylcobalamin-dependent enzyme. Reaction of the enzyme.cofactor complex with 2-aminoacetaldehyde.乙醇胺氨裂解酶(一种依赖腺苷钴胺素的酶)的作用机制。酶-辅因子复合物与2-氨基乙醛的反应。
J Biol Chem. 1978 Feb 25;253(4):1041-7.
7
Interaction of N-substituted ethanolamine analogs with ethanolamine ammonia-lyase, an adenosylcobalamin-requiring enzyme.
J Biol Chem. 1982 Apr 25;257(8):4102-5.
8
The mechanism of action of ethanolamine ammonia-lyase, a B-12-dependent enzyme. The participation of paramagnetic species in the catalytic deamination of 2-aminopropanol.乙醇胺氨裂解酶(一种依赖维生素B12的酶)的作用机制。顺磁物质参与2-氨基丙醇的催化脱氨反应。
J Biol Chem. 1974 Jul 25;249(14):4537-44.
9
The mechanism of action of ethanolamine ammonia-lyase, a B12-dependent enzyme. Evidence for two intermediates in the catalytic process.乙醇胺氨裂解酶(一种依赖维生素B12的酶)的作用机制。催化过程中两个中间体的证据。
J Biol Chem. 1974 Mar 25;249(6):1683-8.
10
Interaction between ethanolamine ammonia-lyase and methylcobalamin. Half-site reactivity with an adenosylcobalamin-dependent enzyme.乙醇胺氨裂解酶与甲钴胺的相互作用。与腺苷钴胺素依赖性酶的半位点反应性。
J Biol Chem. 1975 Dec 10;250(23):8997-9001.

引用本文的文献

1
Kinetic isolation and characterization of the radical rearrangement step in coenzyme B12-dependent ethanolamine ammonia-lyase.辅酶 B12 依赖性乙醇胺氨裂解酶中自由基重排步骤的动力学分离与表征。
J Am Chem Soc. 2010 Jul 21;132(28):9610-5. doi: 10.1021/ja907769g.
2
Probing nitrogen-sensitive steps in the free-radical-mediated deamination of amino alcohols by ethanolamine ammonia-lyase.探究乙醇胺氨裂合酶介导的氨基醇自由基脱氨反应中对氮敏感的步骤。
J Am Chem Soc. 2006 Jun 7;128(22):7120-1. doi: 10.1021/ja060710q.
3
[Vitamin B12 as a biologically active model compound].
[作为生物活性模型化合物的维生素B12]
Naturwissenschaften. 1982 Feb;69(2):63-74. doi: 10.1007/BF00441225.
4
Stereochemistry of the incorporation of valine methyl groups into methylene groups in cephalosporin C.缬氨酸甲基基团掺入头孢菌素C中亚甲基基团的立体化学
Biochem J. 1984 Sep 15;222(3):777-88. doi: 10.1042/bj2220777.
5
The mechanism of cobalamin-dependent rearrangements.钴胺素依赖性重排的机制。
Mol Cell Biochem. 1977 Apr 12;15(2):89-108. doi: 10.1007/BF01793331.