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The mechanism of action of ethanolamine ammonia-lyase, a B12-dependent enzyme. Evidence for two intermediates in the catalytic process.

作者信息

Carty T J, Babior B M, Abeles R H

出版信息

J Biol Chem. 1974 Mar 25;249(6):1683-8.

PMID:4817962
Abstract
摘要

相似文献

1
The mechanism of action of ethanolamine ammonia-lyase, a B12-dependent enzyme. Evidence for two intermediates in the catalytic process.乙醇胺氨裂解酶（一种依赖维生素B12的酶）的作用机制。催化过程中两个中间体的证据。
J Biol Chem. 1974 Mar 25;249(6):1683-8.
2
The mechanism of action of ethanolamine ammonia-lyase, a B-12-dependent enzyme. The participation of paramagnetic species in the catalytic deamination of 2-aminopropanol.乙醇胺氨裂解酶（一种依赖维生素B12的酶）的作用机制。顺磁物质参与2-氨基丙醇的催化脱氨反应。
J Biol Chem. 1974 Jul 25;249(14):4537-44.
3
The mechanism of action of ethanolamine ammonia-lyase, a B12-dependent enzyme. The reversible formation of 5'-deoxyadenosine from adenosylcobalamin during the catalytic process.
J Biol Chem. 1974 Mar 25;249(6):1689-95.
4
The substrate-dependent steric course of the ethanolamine ammonia-lyase reaction.乙醇胺氨裂解酶反应的底物依赖性空间进程。
Eur J Biochem. 1980 May;106(1):211-24. doi: 10.1111/j.1432-1033.1980.tb06012.x.
5
The mechanism of action of ethanolamine ammonia-lyase, an adenosylcobalamin-dependent enzyme. Studies with isopropanolamine, a true substrate.乙醇胺氨裂解酶（一种依赖腺苷钴胺素的酶）的作用机制。以异丙醇胺（一种真正的底物）进行的研究。
J Biol Chem. 1980 Aug 10;255(15):7444-8.
6
Coenzyme-B12-dependent enzyme reactions: a spectrophotometric rapid kinetic study of ethanolamine ammonia-lyase.依赖辅酶B12的酶反应：乙醇胺氨裂解酶的分光光度快速动力学研究
FEBS Lett. 1975 May 1;53(2):193-8. doi: 10.1016/0014-5793(75)80018-4.
7
The mechanism of action of ethanolamine ammonia-lyase, an adenosylcobalamin-dependent enzyme. Evidence that the hydrogen transfer mechanism involves a second intermediate hydrogen carrier in addition to the cofactor.乙醇胺氨裂解酶的作用机制，一种依赖腺苷钴胺素的酶。有证据表明，除辅因子外，氢转移机制还涉及第二种中间氢载体。
J Biol Chem. 1985 Dec 25;260(30):16131-6.
8
The mechanism of action of ethanolamine ammonia-lyase, an adenosylcobalamin-dependent enzyme. Reaction of the enzyme.cofactor complex with 2-aminoacetaldehyde.乙醇胺氨裂解酶（一种依赖腺苷钴胺素的酶）的作用机制。酶-辅因子复合物与2-氨基乙醛的反应。
J Biol Chem. 1978 Feb 25;253(4):1041-7.
9
Deamination of 2-aminopropanol by ethanolamine ammonia-lyase, an AdoCbl-requiring enzyme. Kinetics and isotope effects for the R and S enantiomers of the substrate.乙醇胺氨裂合酶（一种需要腺苷钴胺素的酶）对2-氨基丙醇的脱氨基作用。底物R和S对映体的动力学及同位素效应。
Biochemistry. 1980 Jul 22;19(15):3630-3. doi: 10.1021/bi00556a032.
10
The mechanism of action of ethanolamine ammonia-lyase, an adenosylcobalamin-dependent enzyme. Evidence for a carboxyl group at the active site.乙醇胺氨裂解酶的作用机制，一种依赖腺苷钴胺素的酶。活性位点存在羧基的证据。
J Biol Chem. 1984 Jun 25;259(12):7652-4.

引用本文的文献

1
Expression, crystallization and preliminary X-ray crystallographic study of ethanolamine ammonia-lyase from Escherichia coli.大肠杆菌乙醇胺氨裂解酶的表达、结晶及初步X射线晶体学研究
Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010 Jun 1;66(Pt 6):709-11. doi: 10.1107/S1744309110014478. Epub 2010 May 29.
2
Reaction of the Co(II)-substrate radical pair catalytic intermediate in coenzyme B12-dependent ethanolamine ammonia-lyase in frozen aqueous solution from 190 to 217 K.辅酶B12依赖的乙醇胺氨裂解酶中Co(II)-底物自由基对催化中间体在190至217K的冷冻水溶液中的反应。
Biophys J. 2008 Dec 15;95(12):5890-900. doi: 10.1529/biophysj.108.138081. Epub 2008 Sep 19.
3
The mechanism of cobalamin-dependent rearrangements.
钴胺素依赖性重排的机制。
Mol Cell Biochem. 1977 Apr 12;15(2):89-108. doi: 10.1007/BF01793331.