锂及相关金属离子对大鼠尿中2-氧代戊二酸和柠檬酸排泄的影响。
The effect of lithium and related metal ions on the urinary excretion of 2-oxoglutarate and citrate in the rat.
作者信息
Bond P A, Jenner F A
出版信息
Br J Pharmacol. 1974 Feb;50(2):283-9. doi: 10.1111/j.1476-5381.1974.tb08574.x.
1 Administration of lithium ions to rats, either acutely by intraperitoneal injection or chronically in food, causes increased excretion of 2-oxoglutarate and citrate.2 Chronic administration in food of rubidium and caesium causes decreased excretion of 2-oxoglutarate and citrate.3 The effects described are not due to changes in urine volume, nor pH, nor are they simply related to the excretion of the injected ion.4 Acute administration of lithium caused an increased level of 2-oxoglutarate in kidney and reduced the ratio of glutamate to 2-oxoglutarate.5 Renal gluconeogenesis in slices was only slightly affected by either acute administration of lithium to the animals or by its presence in the incubation medium of renal slices.
给大鼠腹腔注射锂离子进行急性处理，或在食物中慢性添加锂离子，均会导致2-氧代戊二酸和柠檬酸排泄增加。
在食物中慢性添加铷和铯会导致2-氧代戊二酸和柠檬酸排泄减少。
所述效应并非由尿量或pH值的变化引起，也并非简单地与注入离子的排泄有关。
急性给予锂会使肾脏中2-氧代戊二酸水平升高，并降低谷氨酸与2-氧代戊二酸的比例。
对动物急性给予锂或在肾切片孵育培养基中加入锂，对肾切片中的糖异生作用仅有轻微影响。
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