Kozhevnikova K A
Vopr Med Khim. 1979 Mar-Apr;25(2):171-6.
Activity of M2-pyruvate kinase from medullar layer of rabbit kidney was studied in diabetes, in starvation within 1 day and 10-16 days and in long-term starvation of rabbits after administration of glucose or hydrocortisone and protamine-Zn-insulin. The enzymatic activity was increased in diabetes and decreased in long-term starvation and after administration of insulin. A correlation was observed between low activity of pyruvate kinase in kidney medulla under conditions of long-term starvation of rabbits and deficiency of the enzyme substrate. The data, obtained after study of the enzymatic activity in kidney medulla as compared with that of rabbit kidney cortex, demonstrate various adaptability of cells from these kidney layers to regulatory effects of hormones on the pyruvate kinase activity.
研究了糖尿病、饥饿1天和10 - 16天以及长期饥饿的家兔在给予葡萄糖、氢化可的松和精蛋白锌胰岛素后的兔肾髓质层M2 - 丙酮酸激酶活性。糖尿病时酶活性增加，长期饥饿及给予胰岛素后酶活性降低。观察到家兔长期饥饿条件下肾髓质丙酮酸激酶低活性与酶底物缺乏之间的相关性。与兔肾皮质相比，对肾髓质酶活性研究获得的数据表明，这些肾层细胞对激素对丙酮酸激酶活性的调节作用具有不同的适应性。
