用于体外检测对粗球孢子菌免疫力的菌丝体和球形体可溶性抗原。
Soluble antigens of mycelia and spherules in the in vitro detection of immunity to Coccidioides immitis.
作者信息
Deresinski S C, Levine H B, Stevens D A
出版信息
Infect Immun. 1974 Oct;10(4):700-4. doi: 10.1128/iai.10.4.700-704.1974.
Abstract
The effect of a Coccidioides immitis spherule-derived antigen (spherulin) upon in vitro thymidine uptake by sensitized and nonsensitized lymphocytes was studied, and optimal conditions for the assay were determined. The mitogenic portion of the antigen was shown to be nondialyzable, as was true for a mycelial-derived antigen (coccidioidin). Concentrations of 20 mug of nondialyzable spherulin solids and 17 mug of nondialyzable coccidioidin solids per ml of culture were shown to be suitable for differentiating skin test-positive from skin test-negative individuals. Comparison with mycelial filtrate suggested spherulin may be a more potent mitogen for sensitized lymphocytes.
摘要
研究了粗球孢子菌球形体衍生抗原（球孢子菌素）对致敏和未致敏淋巴细胞体外摄取胸苷的影响，并确定了该检测的最佳条件。结果表明，该抗原的促有丝分裂部分不能透析，菌丝体衍生抗原（球孢子菌素）也是如此。每毫升培养物中20微克不可透析的球孢子菌素固体和17微克不可透析的球孢子菌素固体的浓度被证明适用于区分皮肤试验阳性和皮肤试验阴性个体。与菌丝体滤液的比较表明，球孢子菌素可能是致敏淋巴细胞更有效的促有丝分裂原。
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