Schubert G E, Adam A
J Clin Pathol. 1974 Oct;27(10):800-5. doi: 10.1136/jcp.27.10.800.
Light microscopic examination of the kidneys in 170 patients with multiple myeloma revealed three from patients without diabetes with glomerular nodules that were indistinguishable from those of diabetic glomerular sclerosis. Electron microscopic studies showed the nodules to be deposits of fine-grained material that corresponded to precipitations of protein but lacked the basement-membrane-like material characteristic of nodular glomerulosclerosis in diabetics. What is more, a unique collagen was observed in the marginal area of the nodules and in the periglomerular interstitium. The possible causes of the origin and distribution of this collagen not so far described in the human kidney are discussed.
对170例多发性骨髓瘤患者的肾脏进行光学显微镜检查发现，3例无糖尿病患者出现了肾小球结节，这些结节与糖尿病性肾小球硬化症的结节难以区分。电子显微镜研究显示，这些结节是细颗粒物质的沉积物，与蛋白质沉淀相对应，但缺乏糖尿病患者结节性肾小球硬化症特有的基底膜样物质。此外，在结节边缘区域和肾小球周围间质中观察到一种独特的胶原蛋白。本文讨论了这种迄今在人类肾脏中尚未描述的胶原蛋白的起源和分布的可能原因。
