HL-A组织相容性基因与补体第二成分合成相关基因之间存在连锁关系的证据。
Evidence for linkage between HL-A histocompatibility genes and those involved in the synthesis of the second component of complement.
作者信息
Fu S M, Kunkel H G, Brusman H P, Allen F H, Fotino M
出版信息
J Exp Med. 1974 Oct 1;140(4):1108-11. doi: 10.1084/jem.140.4.1108.
Abstract
HL-A analysis of a family with C2 deficiency revealed evidence for close linkage between the C2 defect and the histocompatibility HL-A loci. The propositus was homozygous both for C2 deficiency and the HL-A haplotype 10,W18. Among seven children of three double backcross matings, no recombinants were found. The possible significance of such linkage is discussed.
摘要
对一个患有C2缺陷的家族进行的HL-A分析揭示了C2缺陷与组织相容性HL-A基因座之间紧密连锁的证据。先证者C2缺陷和HL-A单倍型10,W18均为纯合子。在三次双回交交配的七个孩子中，未发现重组体。讨论了这种连锁的可能意义。
相似文献
1
Evidence for linkage between HL-A histocompatibility genes and those involved in the synthesis of the second component of complement.HL-A组织相容性基因与补体第二成分合成相关基因之间存在连锁关系的证据。
J Exp Med. 1974 Oct 1;140(4):1108-11. doi: 10.1084/jem.140.4.1108.
2
Mixed lymphocyte culture determinants and C2 deficiency: LD-7a associated with C2 deficiency in four families.混合淋巴细胞培养决定簇与C2缺乏症：四个家族中与C2缺乏症相关的LD-7a
J Exp Med. 1975 Aug 1;142(2):495-506. doi: 10.1084/jem.142.2.495.
3
Hereditary C2 deficiency: Genetic studies and association with the HL-A system.遗传性C2缺乏症：遗传学研究及其与HL-A系统的关联
J Exp Med. 1975 Jun 1;141(6):1464-9. doi: 10.1084/jem.141.6.1464.
4
Association of C2 deficiency and the HL-A haplotype 10, W18.C2缺乏与HL - A单倍型10、W18的关联
Transplantation. 1975 Aug;20(2):179-80.
5
Genetic linkage between the HL-A system and a deficit of the second component (C2) of complement.HL-A系统与补体第二成分（C2）缺陷之间的遗传连锁。
Science. 1975 Jun 6;188(4192):1020-2. doi: 10.1126/science.1145185.
6
Linkage of gene for C2 deficiency and the major histocompatibility complex MHC in man. Family study of a further case.人类中C2缺乏基因与主要组织相容性复合体（MHC）的连锁关系。另一病例的家系研究。
Vox Sang. 1976;31(2):96-102. doi: 10.1111/j.1423-0410.1976.tb02194.x.
7
Polymorphism of factor B of the properdin system (C3PA, GBG, and Bf) and histocompatibility-complement linkage.备解素系统中B因子（C3PA、GBG和Bf）的多态性与组织相容性-补体连锁
Rev Fr Transfus Immunohematol. 1976 Sep;19(3):471-86. doi: 10.1016/s0338-4535(76)80022-0.
8
The chromosomal order of genes controlling the major histocompatibility complex, properdin factor B, and deficiency of the second component of complement.控制主要组织相容性复合体、备解素因子B和补体第二成分缺陷的基因的染色体顺序。
J Clin Invest. 1976 Nov;58(5):1240-8. doi: 10.1172/JCI108578.
9
Genetic linkage between the HL-A system and a deficit of the second component (C2) of complement in four generations of a family.
Tissue Antigens. 1976 Jan;7(1):35-8. doi: 10.1111/j.1399-0039.1976.tb01026.x.
10
Inherited C2 deficiency and systemic lupus erythematosus: studies on a family.
Ann Intern Med. 1975 Mar;82(3):323-28. doi: 10.7326/0003-4819-82-3-323.
引用本文的文献
1
The Path to Conserved Extended Haplotypes: Megabase-Length Haplotypes at High Population Frequency.保守扩展单倍型之路：高群体频率下的兆碱基长度单倍型
Front Genet. 2021 Aug 6;12:716603. doi: 10.3389/fgene.2021.716603. eCollection 2021.
2
Immunoglobulin deficiencies and susceptibility to infection among homozygotes and heterozygotes for C2 deficiency.C2缺陷纯合子和杂合子中的免疫球蛋白缺陷与感染易感性
J Clin Immunol. 2003 Jul;23(4):297-305. doi: 10.1023/a:1024540917593.
3
Molecular heterogeneity in deficiency of complement protein C2 type I.I型补体蛋白C2缺乏症中的分子异质性
Immunology. 1998 Feb;93(2):184-91. doi: 10.1046/j.1365-2567.1998.00392.x.
4
Complement-human histocompatibility antigen haplotypes in C2 deficiency.C2缺乏症中的补体-人类组织相容性抗原单倍型
J Clin Invest. 1981 Feb;67(2):581-3. doi: 10.1172/JCI110070.
5
Studies on the C2-deficiency gene in man.人类C2缺陷基因的研究。
Immunology. 1980 Apr;39(4):541-9.
6
The location of C2, C4, and BF relative to HLA-B and HLA-D.C2、C4和BF相对于HLA - B和HLA - D的位置。
Immunogenetics. 1981 Mar 1;12(5-6):473-83. doi: 10.1007/BF01561689.
7
Renal transplantation in a patient with hereditary deficiency of the second component of complement.补体第二成分遗传性缺陷患者的肾移植
Clin Exp Immunol. 1981 Nov;46(2):420-4.
8
Quantitative differences between complement factor-B phenotypes.补体因子 B 表型之间的定量差异。
Immunology. 1981 Apr;42(4):505-11.
9
On the significance of C2, C4, and factor B polymorphisms in disease.关于C2、C4和B因子基因多态性在疾病中的意义。
Hum Genet. 1981;56(3):235-47. doi: 10.1007/BF00274674.
10
BF types and the mode of inheritance of insulin-dependent diabetes mellitus (IDDM).胰岛素依赖型糖尿病（IDDM）的BF类型及遗传模式。
Immunogenetics. 1981;12(1-2):59-74. doi: 10.1007/BF01561651.
本文引用的文献
1
Histocompatibility matching. VI. Miniaturization of the mixed leukocyte culture test: a preliminary report.组织相容性匹配。VI. 混合淋巴细胞培养试验的小型化：初步报告。
Transplantation. 1971 Mar;11(3):268-73. doi: 10.1097/00007890-197103000-00005.
2
Ragweed hay fever: genetic control and linkage to HL-A haplotypes.豚草花粉热：遗传控制及与HL - A单倍型的连锁关系
Science. 1972 Dec 15;178(4066):1201-3. doi: 10.1126/science.178.4066.1201.
3
Receptors for immune complexes on lymphocytes.淋巴细胞上免疫复合物的受体
Adv Immunol. 1974;19(0):217-58. doi: 10.1016/s0065-2776(08)60253-9.
4
C2 deficiency. Development of lupus erythematosus.C2缺乏。红斑狼疮的发展。
J Clin Invest. 1973 Jul;52(7):1601-7. doi: 10.1172/JCI107337.
Zotero 插件