Raum D D, Awdeh Z L, Glass D, Yunis E, Alper C A
Immunogenetics. 1981 Mar 1;12(5-6):473-83. doi: 10.1007/BF01561689.
The loci for HLA-A,B,C,D, and DR are known to be closely linked to the structural loci for the complement components C2, BF, and the duplicated loci for C4, C4A and C4B. Conflicting evidence has been presented for the order of these genes. However, new techniques have made possible identification of markers in the HLA-D and C4 region for nearly all identified haplotypes. In our population we have confirmed five HLA-B-D crossovers and in each case informative allotypes of C2, BF, or C4A and C4B segregated with HLA-D or DR suggesting that the loci for these proteins lie close to HLA-D and DR. These findings may be of importance for resolving problems encountered in the assignment of HLA-D alleles.
已知HLA - A、B、C、D和DR的基因座与补体成分C2、BF的结构基因座以及C4的重复基因座C4A和C4B紧密连锁。关于这些基因的顺序存在相互矛盾的证据。然而，新技术使得几乎所有已鉴定单倍型的HLA - D和C4区域中的标记物得以识别。在我们的人群中，我们已经确认了5个HLA - B - D交叉，并且在每种情况下，C2、BF或C4A和C4B的信息性别型与HLA - D或DR分离，这表明这些蛋白质的基因座靠近HLA - D和DR。这些发现对于解决HLA - D等位基因分配中遇到的问题可能具有重要意义。
