The phenyl rings of tricyclic antidepressants and related compounds as determinants of the potency of inhibition of the amine pumps in adrenergic neurons of the rabbit aorta and in rat cortical synaptosomes. - Suppr | 超能文献

The phenyl rings of tricyclic antidepressants and related compounds as determinants of the potency of inhibition of the amine pumps in adrenergic neurons of the rabbit aorta and in rat cortical synaptosomes.

作者信息

Maxwell R A, Ferris R M, Burcsu J, Woodward E C, Tang D, Williard K

出版信息

J Pharmacol Exp Ther. 1974 Dec;191(3):418-30.

Abstract

摘要

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The phenyl rings of tricyclic antidepressants and related compounds as determinants of the potency of inhibition of the amine pumps in adrenergic neurons of the rabbit aorta and in rat cortical synaptosomes.

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2

Kinetic and thermodynamic considerations regarding the inhibition by tricyclic antidepressants of the uptake of tritiated norepinephrine by the adrenergic nerves in rabbit aortic strips.关于三环类抗抑郁药对兔主动脉条中肾上腺素能神经摄取氚化去甲肾上腺素的抑制作用的动力学和热力学考量。

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5

Molecular features affecting the potency of tricyclic antidepressants and structurally related compounds as inhibitors of the uptake of tritiated norepinephrine by rabbit aortic strips.影响三环类抗抑郁药及结构相关化合物作为兔主动脉条摄取氚化去甲肾上腺素抑制剂效力的分子特征。

J Pharmacol Exp Ther. 1969 Apr;166(2):320-9.

6

Concerning the molecular requirements for the inhibition of the uptake of racemic 3 H-norepinephrine into rat cerebral cortex slices by tricyclic antidepressants and related compounds.关于三环类抗抑郁药及相关化合物抑制外消旋3H-去甲肾上腺素摄取进入大鼠大脑皮层切片的分子要求。

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A comparison of the capacities of isomers of amphetamine, deoxypipradrol and methylphenidate to inhibit the uptake of tritiated catecholamines into rat cerebral cortex slices, synaptosomal preparations of rat cerebral cortex, hypothalamus and striatum and into adrenergic nerves of rabbit aorta.对苯丙胺、脱氧哌甲酯和哌醋甲酯的异构体抑制氚标记儿茶酚胺摄取进入大鼠大脑皮层切片、大鼠大脑皮层、下丘脑和纹状体的突触体标本以及兔主动脉肾上腺素能神经的能力进行比较。

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The importance of neuronal uptake of amines for amphetamine-induced release of 3H-norepinephrine from isolated brain tissue.胺类的神经元摄取对于苯丙胺诱导的从离体脑组织中释放3H-去甲肾上腺素的重要性。

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