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The phenyl rings of tricyclic antidepressants and related compounds as determinants of the potency of inhibition of the amine pumps in adrenergic neurons of the rabbit aorta and in rat cortical synaptosomes.

作者信息

Maxwell R A, Ferris R M, Burcsu J, Woodward E C, Tang D, Williard K

出版信息

J Pharmacol Exp Ther. 1974 Dec;191(3):418-30.

PMID:4427288
Abstract
摘要

相似文献

1
The phenyl rings of tricyclic antidepressants and related compounds as determinants of the potency of inhibition of the amine pumps in adrenergic neurons of the rabbit aorta and in rat cortical synaptosomes.
J Pharmacol Exp Ther. 1974 Dec;191(3):418-30.
2
Kinetic and thermodynamic considerations regarding the inhibition by tricyclic antidepressants of the uptake of tritiated norepinephrine by the adrenergic nerves in rabbit aortic strips.关于三环类抗抑郁药对兔主动脉条中肾上腺素能神经摄取氚化去甲肾上腺素的抑制作用的动力学和热力学考量。
J Pharmacol Exp Ther. 1970 Jan;171(1):62-9.
3
Structure-activity relationships for potent phthalane and thiophthalane inhibitors of norepinephrine uptake. A comparison with desipramine and related compounds.去甲肾上腺素摄取的强效苯酞和硫代苯酞抑制剂的构效关系。与地昔帕明及相关化合物的比较。
Mol Pharmacol. 1980 May;17(3):321-7.
4
Conformational similarities between molecular models of phenethylamine and of potent inhibitors of the uptake of tritiated norepinephrine by adrenergic nerves in rabbit aorta.苯乙胺分子模型与兔主动脉中肾上腺素能神经对氚化去甲肾上腺素摄取的强效抑制剂之间的构象相似性。
J Pharmacol Exp Ther. 1970 May;173(1):158-65.
5
Molecular features affecting the potency of tricyclic antidepressants and structurally related compounds as inhibitors of the uptake of tritiated norepinephrine by rabbit aortic strips.影响三环类抗抑郁药及结构相关化合物作为兔主动脉条摄取氚化去甲肾上腺素抑制剂效力的分子特征。
J Pharmacol Exp Ther. 1969 Apr;166(2):320-9.
6
Concerning the molecular requirements for the inhibition of the uptake of racemic 3 H-norepinephrine into rat cerebral cortex slices by tricyclic antidepressants and related compounds.关于三环类抗抑郁药及相关化合物抑制外消旋3H-去甲肾上腺素摄取进入大鼠大脑皮层切片的分子要求。
J Pharmacol Exp Ther. 1971 Sep;178(3):474-81.
7
A comparison of the capacities of isomers of amphetamine, deoxypipradrol and methylphenidate to inhibit the uptake of tritiated catecholamines into rat cerebral cortex slices, synaptosomal preparations of rat cerebral cortex, hypothalamus and striatum and into adrenergic nerves of rabbit aorta.对苯丙胺、脱氧哌甲酯和哌醋甲酯的异构体抑制氚标记儿茶酚胺摄取进入大鼠大脑皮层切片、大鼠大脑皮层、下丘脑和纹状体的突触体标本以及兔主动脉肾上腺素能神经的能力进行比较。
J Pharmacol Exp Ther. 1972 Jun;181(3):407-16.
8
The importance of neuronal uptake of amines for amphetamine-induced release of 3H-norepinephrine from isolated brain tissue.胺类的神经元摄取对于苯丙胺诱导的从离体脑组织中释放3H-去甲肾上腺素的重要性。
J Pharmacol Exp Ther. 1974 Apr;189(1):110-8.
9
On the mechanism of scorpion toxin-induced release of norepinephrine from peripheral adrenergic neurons.关于蝎毒素诱导外周肾上腺素能神经元释放去甲肾上腺素的机制
J Pharmacol Exp Ther. 1974 Jul;190(1):39-48.
10
Inhibition of neuronal uptake of 3H-biogenic amines into rat cerebral cortex by partially and fully saturated derivatives of imipramine and desipramine. The importance of the aromatic ring in adrenergic amines--part 3.丙咪嗪和去甲丙咪嗪的部分及完全饱和衍生物对大鼠大脑皮层中3H-生物胺神经元摄取的抑制作用。芳香环在肾上腺素能胺中的重要性——第3部分。
Biochem Pharmacol. 1979;28(3):417-21. doi: 10.1016/0006-2952(79)90108-4.

引用本文的文献

1
Binding and competitive inhibition of amine uptake at postsynaptic neurones (transport-P) by tricyclic antidepressants.三环类抗抑郁药对突触后神经元胺摄取（转运-P）的结合与竞争性抑制作用。
Br J Pharmacol. 1996 Mar;117(5):811-6. doi: 10.1111/j.1476-5381.1996.tb15265.x.
2
alpha And beta-adrenoceptors in the detrusor muscle and bladder base of the pig and beta-adrenoceptors in the detrusor muscle of man.猪逼尿肌和膀胱底部的α和β肾上腺素能受体以及人逼尿肌中的β肾上腺素能受体。
Br J Pharmacol. 1979 Feb;65(2):215-22. doi: 10.1111/j.1476-5381.1979.tb07821.x.
3
Effect of butyrophenones on the sympathetic nerves of the isolated rabbit heart and on the postsynaptic alpha-adrenoceptors of the isolated rabbit aorta.
Naunyn Schmiedebergs Arch Pharmacol. 1977 Nov;300(3):255-65. doi: 10.1007/BF00500968.