Bischoff K O, Hager W, Bödeker K
Z Kardiol. 1979 Mar;68(3):137-43.
The electrophysiologic effects of dobutamine (D) (3 and/or 6microgram/kg/min), a new beta1 stimulator, was studied in 12 patients with different disturbances of rhythm (sinus-node dysfunction, AV-block, sinus-bradycardia, paroxysmal tachycardia) utilizing His-bundle electrography and right atrial pacing. During infusion of D sinus-rate (HR) increased significantly from 61 to 71/min. Not only in cases with enhanced sinus-node-recovery-time (SKEZ) both, the absolutely (p less than 0.05) and the corrected SKEZ(-18%,-26%) were reduced by D otherwise the calculated sino-atrial-conduction time (SACTc) was shortened only in single cases. No effect could be registered in intraventricular (HV) conduction time, whereas the AV-nodal conduction time (AH) was significantly (p less than 0.05) reduced, more effect was seen at increasing stimulation of heart rate. The intraatrial conduction time (Ah-t) was shortened not significantly. In connection with reduced AH-interval the maximum of conduction frequency of the AV-node was significantly enhanced (10%, 13%). D shortened the refractory-period (RP) of atrium and AV-node, the effect was significant (p less than 0.05) only in the functional-RP of the atrium and relative RP of the AV-node.
使用希氏束电图和右心房起搏技术，对12例患有不同节律紊乱（窦房结功能障碍、房室传导阻滞、窦性心动过缓、阵发性心动过速）的患者，研究了新型β1激动剂多巴酚丁胺（D）（3和/或6微克/千克/分钟）的电生理效应。在输注D期间，窦性心率（HR）从61次/分钟显著增加至71次/分钟。不仅在窦房结恢复时间（SKEZ）延长的病例中，D使绝对SKEZ（p<0.05）和校正后的SKEZ（-18%，-26%）均降低，而且仅在个别病例中计算的窦房传导时间（SACTc）缩短。对室内（HV）传导时间无影响，而房室结传导时间（AH）显著（p<0.05）缩短，心率增加时效应更明显。心房内传导时间（Ah-t）缩短不显著。随着AH间期缩短，房室结的最大传导频率显著提高（10%，13%）。D缩短了心房和房室结的不应期（RP），仅在心房的功能性RP和房室结的相对RP中效应显著（p<0.05）。
