Ritsner M S, Shmidt I R, Shekhner I A, Gurkov Ia V, Stankov I A
Zh Nevropatol Psikhiatr Im S S Korsakova. 1979;79(4):409-13.
The paper contains a comparative analysis of the distribution of the blood groups of the ABO system in 1731 patients with syndromes of spinal osteochondrosis and in 9013 representatives of the population. Besides the frequency indices the authors studied as well the index of a relative morbidity A/O the "racial-biochemical" Hirshfeld index and the relationship of the frequency of group 0 to the sum of frequency in the A, B, AB group. It was demonstrated that there was a significant drop in patients with spinal osteochondrosis of the frequency of the 0 group and an increase of the group A. These deviations demonstrate a correlation with the sex, age by the onset, localization of the process longitudinally to the spine and hereditary loading (cases of repeated cases in the family). The revealed regularities may be considered as evidence of the influence of the genotype on the development of spinal osteochondrosis as well as one of the mechanisms determining the immune response in this disease.
该论文对1731例脊柱骨软骨病综合征患者和9013名人群代表的ABO血型系统分布进行了比较分析。除频率指标外，作者还研究了相对发病率A/O指数、“种族生化”赫希菲尔德指数以及O组频率与A、B、AB组频率总和的关系。结果表明，脊柱骨软骨病患者中O组频率显著下降，A组频率增加。这些偏差表明与性别、发病年龄、病变在脊柱纵向的定位以及遗传负荷（家族中反复发病的病例）相关。所揭示的规律可被视为基因型对脊柱骨软骨病发展影响的证据，以及该疾病中决定免疫反应的机制之一。
