Friede R L, Bischhausen R
Acta Neuropathol. 1979 Mar 15;45(3):241-5. doi: 10.1007/BF00702676.
Formation of myelin sheaths by neoplastic cells was found in a spinal ganglioneuroma. All phases of initial myelination were observed including the formation of a mesaxonal spiral and the fusion of its lamellae into a major dense line. A unique aspect of neoplastic myelin formation was the formation of sheaths around bundles of extracellular fibrils rather than axons or cell processes. Formation of myelin sheaths around extracellular material has never been observed before. The findings have implications on the mechanisms controlling initial myelination.
在一例脊髓神经节神经瘤中发现肿瘤细胞形成髓鞘。观察到了初始髓鞘形成的各个阶段，包括轴系膜螺旋的形成及其薄片融合成一条主要致密线。肿瘤性髓鞘形成的一个独特方面是在细胞外原纤维束周围形成髓鞘，而不是在轴突或细胞突起周围。此前从未观察到在细胞外物质周围形成髓鞘。这些发现对控制初始髓鞘形成的机制具有启示意义。
