Göthberg G, Lundin S, Ricksten S E, Folkow B
Acta Physiol Scand. 1979 Mar;105(3):282-94. doi: 10.1111/j.1748-1716.1979.tb06343.x.
In maximally vasodilated SHR and NCR kidneys, perfused with filtrable and non-filtrable perfusates, analyses have been performed concerning the extent of average renal tissue pressure (Pt) elevation which occurs upon glomerular filtration and causes passive autoregulation of flow. The results illustrate the great importance of distinguishing between 'apparent' (PA--PV/flow) and 'true' (PA--Pt/flow) renal resistance to flow. This is particularly so when the compared SHR and NCR renal vascular beds differ not only in true total renal resistance but also concerning the structurally determined ratio between the pre- and post-glomerular resistances. The combined results show that this ratio is considerably elevated in adults SHT kidneys because of structural vascular changes, which is perhaps the most efficient way of resetting the 'long term barostat function' of the kidneys in hypertension. It is also illustrated how the altered pre-/post-glomerular ratio in SHR in combination with Pt rises can so markedly distort the results of apparently precise in vitro comparisons of SHR and NCR renal vascular beds as to give entirely misleading results, with underestimations of the structurally based vascular hyperreactivity of the preglomerular section in SHR.
在使用可滤过和不可滤过灌注液灌注的最大血管扩张的SHR和NCR肾脏中，已对肾小球滤过过程中发生的平均肾组织压力（Pt）升高程度进行了分析，该升高会导致流量的被动自动调节。结果表明区分“表观”（PA - PV/流量）和“真实”（PA - Pt/流量）肾血流阻力非常重要。当比较的SHR和NCR肾血管床不仅在真实的总肾阻力方面不同，而且在肾小球前和肾小球后阻力的结构决定比例方面也不同时，情况尤其如此。综合结果表明，由于结构性血管变化，成年SHR肾脏中的这一比例显著升高，这可能是高血压中重置肾脏“长期压力调节功能”的最有效方式。还说明了SHR中改变的肾小球前/后比例与Pt升高相结合，如何能如此显著地扭曲SHR和NCR肾血管床明显精确的体外比较结果，从而给出完全误导性的结果，低估了SHR中基于结构的肾小球前节段血管高反应性。
