Göthberg G, Folkow B
Acta Physiol Scand. 1983 Apr;117(4):547-55. doi: 10.1111/j.1748-1716.1983.tb07225.x.
Maximally dilated renal vascular beds of 13-month-old NCR and SHR were compared to explore how aging respectively longstanding primary hypertension structurally alters total renal resistance, pre/postglomerular resistance ratio and maximal glomerular filtration capacity, as measured per unit kidney weight. According to comparisons of 1.5- and 3.5-month-old NCR and SHR (Folkow et al. 1977), a structurally increased pre/postglomerular resistance ratio rapidly resets the renal "longterm barostat function" in SHR to match the 30-40% pressure rise, thereby increasing total renal resistance 15-20%, while filtration capacity is unaltered so far. In NCR aging to 13 months hardly alters arterial pressure, but increases total renal resistance 10-15%, mainly affecting postglomerular vessels, while filtration capacity is reduced 25%. 13-month-old SHR show an additional 15% pressure rise and--relative to agematched NCR--a further 35% reduction of filtration capacity with a 30-35% increase of total renal resistance, which mainly affects the postglomerular vessels as the resistance ratio is now barely above that in NCR. Thus, advancing SHR hypertension seems to start a renal vicious circle, because accentuated reductions of filtration capacity are parallelled by structural postglomerular resistance increases apparently to maintain GFR by raised filtration pressure which, however, accelerates glomerular deterioration.
比较13月龄正常血压大鼠（NCR）和自发性高血压大鼠（SHR）的肾血管床最大扩张情况，以探究衰老以及长期原发性高血压如何分别在结构上改变总肾阻力、肾小球前/后阻力比和最大肾小球滤过能力（以每单位肾脏重量衡量）。根据对1.5月龄和3.5月龄NCR和SHR的比较（Folkow等人，1977年），结构上增加的肾小球前/后阻力比会迅速重置SHR的肾“长期压力调节功能”，以匹配30%-40%的血压升高，从而使总肾阻力增加15%-20%，而到目前为止滤过能力未改变。在NCR中，衰老至13个月几乎不会改变动脉血压，但会使总肾阻力增加10%-15%，主要影响肾小球后血管，同时滤过能力降低25%。13月龄的SHR血压额外升高15%，并且相对于年龄匹配的NCR，滤过能力进一步降低35%，总肾阻力增加30%-35%，这主要影响肾小球后血管，因为此时阻力比仅略高于NCR。因此，SHR高血压的进展似乎启动了一个肾恶性循环，因为滤过能力的显著降低与肾小球后结构阻力的增加同时出现，显然是为了通过升高滤过压来维持肾小球滤过率（GFR），然而这会加速肾小球的恶化。
