Mischler E H, Chesney P J, Chesney R W, Mazess R B
Am J Dis Child. 1979 Jun;133(6):632-5. doi: 10.1001/archpedi.1979.02130060072016.
Bone mineral content, bone width, and their ratio were measured in patients with cystic fibrosis (CF) using monoenergetic photon absorptiometry. Serial measurements of the radius and ulna were made in 27 patients with CF and were compared with 968 age-matched controls. Demineralization was found in 37% of the boys and 63% of the girls. Patients under age 10 years had normal bone mineral content and nine of 15 patients aged 13 or older were demineralized (P less than .01). Demineralization correlated with the extent of weight reduction in patients (P less than .001). Patients most likely to be demineralized were adolescent girls. To our knowledge, this is the first report of bone mineral status of children with CF, and the results indicate that a sizable proportion of these patients may be demineralized without overt rickets.
采用单能光子吸收法对囊性纤维化（CF）患者的骨矿物质含量、骨宽度及其比值进行了测量。对27例CF患者的桡骨和尺骨进行了系列测量，并与968名年龄匹配的对照者进行了比较。发现37%的男孩和63%的女孩存在骨质减少。10岁以下的患者骨矿物质含量正常，15名13岁及以上患者中有9名存在骨质减少（P<0.01）。骨质减少与患者体重减轻程度相关（P<0.001）。最有可能出现骨质减少的患者是青春期女孩。据我们所知，这是关于CF患儿骨矿物质状况的首次报告，结果表明这些患者中有相当一部分可能存在骨质减少但无明显佝偻病。
