Kim J H, Kim S H, Hahn E
Am J Roentgenol Radium Ther Nucl Med. 1974 Aug;121(4):860-4. doi: 10.2214/ajr.121.4.860.
Cultures of normal tissue are relatively insensitive to heat, while malignant cells in culture are highly sensitive to thermal treatment. This differential thermal sensitivity is most pronounced when the cells of normal and neoplastic tissues are exposed to heat in their exponential growth phase. Dose survival curves of HeLa and 3T3 cells with and without postirradiation thermal treatment showed that the neoplastic HeLa line exhibited significant enhancement of radiosensitivity when the irradiated cells were exposed to elevated temperatures (42C. for 3 hours). Similar heat treatment of irradiated 3T3 fibroblasts did not appreciably enhance the radiation response. The potential significance of these findings for clinical radiotherapy is discussed.
正常组织培养物对热相对不敏感，而培养中的恶性细胞对热处理高度敏感。当正常组织和肿瘤组织的细胞在指数生长期受热时，这种热敏感性差异最为明显。有和没有照射后热处理的HeLa细胞和3T3细胞的剂量存活曲线表明，当受照射细胞暴露于升高的温度（42℃，持续3小时）时，肿瘤性HeLa细胞系表现出显著的放射敏感性增强。对受照射的3T3成纤维细胞进行类似的热处理并没有明显增强其辐射反应。讨论了这些发现对临床放射治疗的潜在意义。
