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一种用于在笼养狒狒中直接测量心血管功能的系留系统。

A tethering system for direct measurement of cardiovascular function in the caged baboon.

作者信息

Byrd L D

出版信息

Am J Physiol. 1979 May;236(5):H775-9. doi: 10.1152/ajpheart.1979.236.5.H775.

DOI:10.1152/ajpheart.1979.236.5.H775
PMID:443399
Abstract

A device suitable for the continuous measurement of physiological activity in large, conscious monkeys has permitted the direct recording of systemic arterial blood pressure and heart rate in caged baboons. The device comprises a lightweight fiberglass backpack, retained in place on the baboon by a thoracic elastic band and shoulder straps, and a flexible stainless steel tether connecting the pack to an electrocannular slip-ring in the top center of the baboon's cage. A chronically indwelling arterial catheter inserted retrograde into the abdominal aorta via the internal iliac artery and connected to a small pressure transducer on the pack provides direct measurement of blood pressure and heart rate. Body fluids can be sampled or drugs administered via an indwelling catheter in the inferior vena cava. Electrical and fluid connections between the fiberglass pack and recording and infusion equipment located outside the cage pass through the flexible tether and remain protected from the subject. The reliability of the tethering system has been demonstrated in physiological, pharmacological, and behavioral experiments with baboons.

摘要

一种适用于对大型清醒猴子的生理活动进行连续测量的装置,已能够在笼养狒狒中直接记录体循环动脉血压和心率。该装置包括一个轻质玻璃纤维背包,通过胸部弹性带和肩带固定在狒狒身上,以及一条柔性不锈钢系绳,将背包连接到狒狒笼顶部中央的电环形滑环上。通过髂内动脉逆行插入腹主动脉并连接到背包上的一个小型压力传感器的长期留置动脉导管,可直接测量血压和心率。体液可通过下腔静脉中的留置导管进行采样或给药。玻璃纤维背包与位于笼外的记录和输液设备之间的电气和流体连接通过柔性系绳,并且受到保护,不会被实验对象接触到。系绳系统的可靠性已在狒狒的生理、药理和行为实验中得到证明。

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