Blaine E H, Zimmerman M B
Am J Physiol. 1979 Jun;236(6):F546-51. doi: 10.1152/ajprenal.1979.236.6.F546.
Uninephrectomized ewes were prepared with a renal artery flow probe and catheters were implanted into the renal artery, vein, and ureter. The renal perfusion pressure (RPP) of conscious animals was decreased externally by 13 +/- 3, 21 +/- 3, 31 +/- 3 mmHg over 5 min and returned to control levels over 5 min. Reduction of RPP by 13 and 21 mmHg resulted in prompt increases in renin secretion (RS) which were maximal coincident with the nadir of the downward ramp (delta RS 195 +/- 43 P less than 0.05, and 1,077 +/- 208 ng AI/min, P less than 0.01, respectively). Directly measured renal blood flow (RBF) was not decreased and no measurable change occured in GFR. When RPP was reduced by 31 mmHg, RBF and GFR were decreased and renin secretion rose further (delta RS 1,480 +/- 384 AI/min, P less than 0.05). On the upward pressure ramp, RS fell promptly and was nearly at control levels upon restoration of RPP. It was concluded that renin secretion responds rapidly to alterations in RPP in the autoregulatory range and these changes in renin secretion are unlikely to be mediated by a tubular receptor.
对单肾切除的母羊安装肾动脉血流探头，并将导管分别植入肾动脉、肾静脉和输尿管。清醒动物的肾灌注压（RPP）在5分钟内分别外源性降低13±3、21±3、31±3 mmHg，并在随后的5分钟内恢复至对照水平。RPP降低13 mmHg和21 mmHg时，肾素分泌（RS）迅速增加，在压力下降斜率最低点时达到最大值（肾素分泌变化量分别为195±43 pg，P<0.05；1077±208 ng AI/min，P<0.01）。直接测量的肾血流量（RBF）未降低，肾小球滤过率（GFR）也无显著变化。当RPP降低31 mmHg时，RBF和GFR降低，肾素分泌进一步增加（肾素分泌变化量为1480±384 AI/min，P<0.05）。在压力上升阶段，肾素分泌迅速下降，RPP恢复后几乎降至对照水平。研究得出结论，在自动调节范围内，肾素分泌对RPP的变化反应迅速，且这些肾素分泌的变化不太可能由肾小管受体介导。
