Williams K H, Goldstein G
Am J Psychiatry. 1979 Jun;136(6):800-3. doi: 10.1176/ajp.136.6.800.
The authors describe a series of patients with organic brain syndrome who showed a dramatic clinical response to lithium carbonate therapy. None of the patients had been diagnosed as manic-depressive. Most had extensive psychiatric treatment experiences and had been given both affective and cognitive diagnoses. Six of the eight patients also qualified for the diagnosis of alcoholism. They had been treated with a wide variety of psychotherapeutic medications. Lithium was found to be rapidly and dramatically effective in patients with static lesions of the central nervous system who showed a combination of dementia and agitated depression.
作者描述了一系列患有器质性脑综合征的患者，他们对碳酸锂治疗表现出显著的临床反应。这些患者均未被诊断为躁郁症。大多数患者有丰富的精神科治疗经历，且曾被给予情感和认知方面的诊断。八名患者中有六名也符合酒精中毒的诊断标准。他们曾接受过各种各样的精神治疗药物治疗。结果发现，锂对患有中枢神经系统静态病变且表现出痴呆与激越性抑郁相结合症状的患者具有迅速且显著的疗效。
