Bacher N M, Lewis H A
Am J Psychiatry. 1979 Jun;136(6):811-4. doi: 10.1176/ajp.136.6.811.
The authors report on six refractory manic or schizo-affective manic male outpatients who failed to respond to lithium combined with a neuroleptic. A beneficial response was noted in most patients when reserpine was substituted for their currently prescribed standard neuroleptic; in some cases lithium dosage could then be reduced. No major side effects were encountered. The use of reserpine may offer an alternative mode of therapy for manic patients who cannot tolerate large doses of lithium or do not completely respond to lithium either alone or in combination with a standard neuroleptic.
作者报告了6例难治性躁狂或分裂情感性躁狂男性门诊患者，他们对锂盐联合抗精神病药物治疗无效。当用利血平替代他们目前 prescribed 的标准抗精神病药物时，大多数患者出现了有益反应；在某些情况下，随后可以减少锂盐剂量。未出现严重副作用。对于不能耐受大剂量锂盐或单独使用锂盐或与标准抗精神病药物联合使用时未完全反应的躁狂患者，使用利血平可能提供一种替代治疗方式。
