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Identification of norcocaine as a metabolite of (3H)-cocaine in rat brain.

作者信息

Misra A L, Nayak P K, Patel M N, Vadlamani N L, Mulé S J

出版信息

Experientia. 1974 Nov 15;30(11):1312-4. doi: 10.1007/BF01945203.

DOI:10.1007/BF01945203
PMID:4435177
Abstract
摘要

相似文献

1
Identification of norcocaine as a metabolite of (3H)-cocaine in rat brain.鉴定去甲可卡因作为（3H）-可卡因在大鼠脑中的一种代谢产物。
Experientia. 1974 Nov 15;30(11):1312-4. doi: 10.1007/BF01945203.
2
[3H]-Noncocaine and [3H]-pseudococaine: effect of N-demethylation and C2-epimerization of cocaine on its pharmacokinetics in the rat.
Experientia. 1976;32(7):895-7. doi: 10.1007/BF02003753.
3
Metabolism of norcocaine, N-hydroxy norcocaine and cocaine-N-oxide in the rat.大鼠体内去甲可卡因、N-羟基去甲可卡因和可卡因-N-氧化物的代谢
Xenobiotica. 1979 Mar;9(3):189-99. doi: 10.3109/00498257909038720.
4
Norcocaine: a pharmacologically active metabolite of cocaine found in brain.去甲可卡因：一种在大脑中发现的可卡因的药理活性代谢物。
Life Sci. 1974 Dec 15;15(12):2189-95. doi: 10.1016/0024-3205(74)90035-6.
5
Metabolism correlates of cocaine-induced stereotypy in rats.大鼠中可卡因诱导的刻板行为的代谢相关性
Pharmacol Biochem Behav. 1979 Feb;10(2):267-71. doi: 10.1016/0091-3057(79)90099-6.
6
Cocaine and alcohol interactions in the rat: contribution of cocaine metabolites to the pharmacological effects.大鼠体内可卡因与酒精的相互作用：可卡因代谢产物对药理作用的影响
J Pharm Sci. 1999 Apr;88(4):468-76. doi: 10.1021/js980283h.
7
Intracellular disposition of (3H)-cocaine, (3H)-norcocaine, (3H)-benzoylecgonine and (3H)-benzoylnorecgonine in the brain of rats.（3H）-可卡因、（3H）-去甲可卡因、（3H）-苯甲酰爱康宁和（3H）-苯甲酰去甲爱康宁在大鼠脑中的细胞内分布情况。
Life Sci. 1976 Nov 15;19(10):1585-96. doi: 10.1016/0024-3205(76)90105-3.
8
Biotransformation of norcocaine to norcocaine nitroxide by rat brain microsomes.大鼠脑微粒体将去甲可卡因转化为去甲可卡因氮氧化物。
Psychopharmacology (Berl). 1984;84(2):221-4. doi: 10.1007/BF00427449.
9
Physiologic disposition and metabolism of (3H) ecgonine (cocaine metabolite) in the rat.（3H）芽子碱（可卡因代谢物）在大鼠体内的生理分布与代谢
Res Commun Chem Pathol Pharmacol. 1974 May;8(1):55-63.
10
Estimation and disposition of [3H]benzoylecgonine and pharmacological activity of some cocaine metabolites.[3H]苯甲酰爱康宁的估算与处置及某些可卡因代谢物的药理活性
J Pharm Pharmacol. 1975 Oct;27(10):784-6. doi: 10.1111/j.2042-7158.1975.tb09404.x.

引用本文的文献

1
Potential Molecular Mechanisms on the Role of the Sigma-1 Receptor in the Action of Cocaine and Methamphetamine.西格玛-1受体在可卡因和甲基苯丙胺作用中的潜在分子机制
J Drug Alcohol Res. 2016 Feb 20;5. doi: 10.4303/jdar/235970.
2
Initial locomotor sensitivity to cocaine varies widely among inbred mouse strains.不同近交系小鼠对可卡因的初始运动敏感性差异很大。
Genes Brain Behav. 2015 Mar;14(3):271-80. doi: 10.1111/gbb.12209.
3
The impact of early environmental rearing condition on the discriminative stimulus effects and Fos expression induced by cocaine in adult male and female rats.

本文引用的文献

1
Distribution and metabolism of cocaine in the dog and rabbit.可卡因在犬和兔体内的分布与代谢。
J Pharmacol Exp Ther. 1951 Feb;101(2):200-4.
2
Mechanism of action of cocaine and amphetamine in the brain.可卡因和安非他命在大脑中的作用机制。
Experientia. 1962 May 15;18:229-31. doi: 10.1007/BF02148316.
3
Self-administration of psychoactive substances by the monkey.
Psychopharmacologia. 1969;16(1):30-48. doi: 10.1007/BF00405254.
早期环境饲养条件对成年雄性和雌性大鼠中可卡因诱导的辨别性刺激效应及Fos表达的影响。
Psychopharmacology (Berl). 2009 Apr;203(2):383-97. doi: 10.1007/s00213-008-1368-4. Epub 2008 Oct 25.
4
Intravenous self-administration of cocaine and norcocaine by dogs.狗静脉注射可卡因和去甲可卡因的自我给药行为。
Psychopharmacology (Berl). 1980;71(1):83-9. doi: 10.1007/BF00433258.
5
Endogenous peptide(s) inhibiting [3H]cocaine binding in mouse brain.抑制小鼠脑中[3H]可卡因结合的内源性肽
Neurochem Res. 1980 Dec;5(12):1291-9. doi: 10.1007/BF00964964.
6
Biotransformation of norcocaine to norcocaine nitroxide by rat brain microsomes.大鼠脑微粒体将去甲可卡因转化为去甲可卡因氮氧化物。
Psychopharmacology (Berl). 1984;84(2):221-4. doi: 10.1007/BF00427449.
7
[3H]-Noncocaine and [3H]-pseudococaine: effect of N-demethylation and C2-epimerization of cocaine on its pharmacokinetics in the rat.
Experientia. 1976;32(7):895-7. doi: 10.1007/BF02003753.
4
Persistence of morphine in central nervous system of rats after a singel injection and its bearing on tolerance.
Nature. 1971 Jul 2;232(5305):48-50. doi: 10.1038/232048a0.
5
Pharmacokinetics and metabolism of (3H) thebaine.（3H）蒂巴因的药代动力学与代谢
Xenobiotica. 1974 Jan;4(1):17-32. doi: 10.3109/00498257409052087.
6
Relationship of pharmacokinetic and metabolic parameters to the absence of physical dependence liability with thebaine-3H.药代动力学和代谢参数与蒂巴因 - 3H不存在身体依赖性倾向的关系。
Experientia. 1973 Sep 15;29(9):1108-10. doi: 10.1007/BF01946748.
7
Physiological disposition and metabolism of levo-methadone-1- 3 H in nontolerant and tolerant rats.左旋美沙酮-1-³H在未耐受和耐受大鼠体内的生理处置与代谢
J Pharmacol Exp Ther. 1973 May;185(2):287-99.
8
Persistence of methadone-3H and metabolite in rat brain after a single injection and its implications on pharmacological tolerance.
Nature. 1972 Jul 21;238(5360):155-7. doi: 10.1038/238155a0.
9
Stereoselectivity and differential metabolism in vivo of dextro and laevo-methadone-1- 3 H.右旋和左旋美沙酮-1-³H在体内的立体选择性和差异代谢
Nature. 1973 Jan 26;241(5387):281-3. doi: 10.1038/241281a0.
10
Supersensitivity and dependence on cocaine.对可卡因的超敏反应和依赖。
Nature. 1968 Dec 28;220(5174):1327-8. doi: 10.1038/2201327a0.