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[3H]-Noncocaine and [3H]-pseudococaine: effect of N-demethylation and C2-epimerization of cocaine on its pharmacokinetics in the rat.

作者信息

Misra A L, Pontani R B, Mule' S J

出版信息

Experientia. 1976;32(7):895-7. doi: 10.1007/BF02003753.

DOI:10.1007/BF02003753
PMID:954975
Abstract

After i.v. injections of cocaine, norcocaine, pseudococaine to the rat, the T 1/2 in brain were 0.4, 0.6, 0.2 h respectively and in plasma 0.4, 0.5, 0.2 h respectively. Benzoylnorecgonine and norecgonine were the metabolites of norcocaine in brain. Pseudonorcocaine, pseudobenzoylnorecgonine, pseudobenzoylecgonine and pseudoecgonine were the metabolites of pseudococaine in rat brain. Benzolynorecgonine and pseudobenzoylecgonine had potent stimulant activity intracisternally in the rats.

摘要

相似文献

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3

本文引用的文献

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[Central effects of cocaine homologues and their modification by reserpine and adrenolytics].[可卡因同系物的中枢效应及其被利血平和肾上腺素能阻滞剂的修饰作用]
Naunyn Schmiedebergs Arch Exp Pathol Pharmakol. 1962;243:148-61.
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Alpha-cocaine.α-可卡因
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J Pharmacol Exp Ther. 1972 Aug;182(2):273-83.
7
Pharmacokinetics and metabolism of (3H) thebaine.（3H）蒂巴因的药代动力学与代谢
Xenobiotica. 1974 Jan;4(1):17-32. doi: 10.3109/00498257409052087.
8
Norcocaine: a pharmacologically active metabolite of cocaine found in brain.去甲可卡因：一种在大脑中发现的可卡因的药理活性代谢物。
Life Sci. 1974 Dec 15;15(12):2189-95. doi: 10.1016/0024-3205(74)90035-6.
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Persistence of methadone-3H and metabolite in rat brain after a single injection and its implications on pharmacological tolerance.
Nature. 1972 Jul 21;238(5360):155-7. doi: 10.1038/238155a0.
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Identification of norcocaine as a metabolite of (3H)-cocaine in rat brain.鉴定去甲可卡因作为（3H）-可卡因在大鼠脑中的一种代谢产物。
Experientia. 1974 Nov 15;30(11):1312-4. doi: 10.1007/BF01945203.