人免疫球蛋白G亚类在兔胎儿卵黄囊中的转运
Transport of the subclasses of human IgG across the yolk-sac of the foetal rabbit.
作者信息
Hemmings W A
出版信息
Immunology. 1974 Oct;27(4):693-7.
The four subclasses of human IgG were labelled either with I or I and injected into rabbit uteri (24 days pregnant) in pairs. Transmission to the foetal circulation was measured 1 day later. It was found that all four sub-classes are transmitted, though IgG1 enters most readily. Whole labelled human IgG fast and slow electrophoretic fractions prepared by DEAE chromatography were also injected and an isoelectrofocusing analysis carried out on the injected IgG and the foetal serum. There was considerable variation of transmission even between adjacent peaks of the IEF pattern.
将人IgG的四个亚类分别用I或I标记，然后成对注入怀孕24天的兔子宫。1天后测定其向胎儿循环的传递情况。结果发现所有四个亚类均可传递，不过IgG1最易进入。还注射了通过DEAE色谱法制备的完整标记人IgG的快、慢电泳级分，并对注入的IgG和胎儿血清进行等电聚焦分析。即使在IEF图谱的相邻峰之间，传递情况也存在相当大的差异。
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